Colchicine

Chemical name

(S)-N-(5,6,7,9-Тетрагидро-1,2, 3,10-тетраметокси-9-оксо бензо[a]гептален- 7-il) acetamid

Gross

C22-H25-N-O6

Characteristics

D. clubnelukovic bezwremennika magnificent (A.severtzovi Speciosum Stev). Lileynah family. White or white with a yellowish sheen melkochristalliceski powder temneuschi to light. 1 g dissolved in 25 ml of water and 220 ml of ether, easily soluble in ethanol and chloroform.

Of drugs

The drugs-protivopodagricescoe, pain. And antimitoticescoy activity oppressing leiko- and limfopoez, reduces glucose utilization and faguoqitirutmi nefaguoqitirutmi leikotitami, stabilize membranes lizosom Klebsiella to prevent the formation amiloidnykh fibrill. Violate neuromuscular transmission, stimulates the digestive tract, inhibits breathing center, narrow vessels and increases AD lowers the temperature Tela.bystro absorbed in the digestive tract, is kishechno-pechenocna recycling. There is not associated with plasma proteins and fixed in systemic blood. In high concentrations accumulate in the kidneys, liver and spleen. Excreted mainly jelchew through Pocki.vsoko operational for cupping podagricescoy acute attacks. Antipodagriceski effect depends on the level of leikozitah rather than in the plasma and attributable to the lower release of lysosomal enzymes from Klebsiella, declining education lactate, pH stabilization tissue fluid restriction and crystallization of uric acid. Противовоспалительно е is the only scrophulosis artritah : affects primary vospalitionuu reactions, including vospalitionuu local infiltration granulozitami, faguoqitirutmi uratov crystals, and the best result is the early start of treatment (shortly after the onset of symptoms). During the first 12 hours of therapy have improved more than 75% of patients. The 80% of adverse reactions from the blood, which may occur before clinical improvement or at the same time. The on / in the application side effects from the stomach do not develop and the patient is improving faster. After a single injection of the leikozitah increases and did not change in 24 hours The daily dose of 1-2 mg with a daily admission to the 3 / 4 patients with podagra reduces the likelihood of repeated violent attacks. Warn acute attacks in patients family Mediterranean fever (reduced activity дофамин-бета-гидрокси лазы). Increases life expectancy of patients with primary Al-amiloidozom. It has a positive effect on the skin (reduced, reducing dryness) with progressive systemic EMG (sclerodermia). Effective in mild Behceta syndrome, the primary biliarnom cirrhosis. Wrinkles progressive neurological disorders in distributed EMG.

Indications

Acute gouty attack, preventing relapse of acute scrophulosis attacks, especially in the first two years after the start of the reception gipouriquemicakih funds sklerodermia system, amiloidoz illness Behceta, family Mediterranean fever.

Contraindications

Hypersensitivity, damage blood, bone marrow, neutropenia, a breach of the liver and kidneys, heart disease, fatigue infection, alcoholism, pregnancy, old age.

Side-Effects

Diarrhoeal events (nausea, vomiting, anorexia, diarrhoea, etc.) arising from the ingestion of high doses mielosuprescia (lakopenia, agranulozitos, aplastic anemia, thrombocytopenia, usually in the long-term care), the temporary alopecia, liver failure, increased alkaline phosphatase and gamma-glutamiltranspeptidaza violation of the kidneys, depression, miopatia and peripheral neuritis, obratimaya aspermia, malabsorbtion syndrome that surfaces in particular, vitamin B_12, skin allergies local irritation with the in / in the introduction and ekstravazace-sharp pain necrosis.

Specific guidance

There absorption reaction urine on haemoglobin and blood.

Patient interaction

Do effect deprimiruth and simpatomimeticakih funds. Violate intake of vitamin B_12. NPVS and other preparations of mielodepressiu, increase the risk of hemorrhagic and trombozitopenia. Protivopodagricescuu activity reduces cytostatics (increase the concentration of uric acid).

Overdosing

Symptoms : nausea, vomiting, severe diarrhea, pain in the abdomen and in the mouth, bloody gastroenteritis, skin burns, severe dehydration to suffer and gipovolemicakim shock, the decrease sokratimosti attacks and the rise of ST segment on ECG, gematuria, oliguria, convulsions, paralysis up, respiratory depression. Perhaps the gepatozellliarnogo damage, acute renal failure, pulmonary infiltrates. Five days after the overdose can lead to severe oppression bone marrow with lakopenia, trombozitopenia, Koagulopatia.lechenie : to be held in the poison center. Specific antidote not. Haemodialysis ineffective. There is a need for monitoring of cross respiratory tract auxiliary ventilation, monitoring and maintenance of the vital functions, the normalization of the gaseous composition of the blood, elektrolitnogo balance, the protivosokovh activities.

Precautions

When expressed side effects from the stomach to reduce the dose or stop the drug. When the cells below × ^ 9 / l, and platelets below 100h10 ^ 9 / l reception cease to reconstruct the blood. Treatment should be carefully and clinical gematologicakim control periodically examine the device hidden blood.

Dosing and Administration

Inside. In acute gout attacks and inflammatory processes : in the first day, 1 mg three times a day (morning, afternoon and evening), the second and third day, and 1 mg twice a day (morning and evening) at the 4th and in the following days, and 1 mg / day (evening). The second pattern : the initial dose of 1 mg, then 0.5-1.5 mg every 1-2 hours before the disappearance pain. The maximum daily dose of 6 mg. To prevent gout-1 mg evening; Course-3m. In periodic sickness, pregnancy amiloidozom-term (up to 5 years or more) to 1-1.5 mg / day.

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