Kolhikum-dispert

Roman name

Colchicum-dispert

Characteristics

Somber round brilliant pill Film-coated.

Pharmacokinetics

Quickly and intensely absorbed from the digestive tract. S_max in plasma following the admission dose of 1 mg of 4.2 ng / ml and is a 70 min. T_1/2 9.3 hours Quickly penetrates the tissues, the level of 473-litres. The highest concentrations are found in the liver, kidney, spleen, leikozitah and digestive tract. Metabolised sauce, and presented mainly to the jelchew intestine, and about 23% through the kidneys. Once inside enterogepatical circulation found four to six hours

Farmakodinamika

Effective for short-acute gout : in the first 12 hours of therapy have improved the 75% of patients (80% of patients of the side effects of blood to clinical improvement or at the same time). Decreases risk of developing recurrent acute attack of 3 / 4 patients with a daily admission to a daily dose of 1-2 mg. Warn acute attack of the family bolanh Mediterranean fever (reduced activity дофамин-бета-гидрокси лазы). Increases life expectancy of patients with primary Al-amiloidozom. It has positive effects on the skin with systemic sclerodermia (reduced, reducing dryness).

Indications

Gout (acute attack, prevention scrophulosis attacks), recurrent disease (family Mediterranean fever).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, liver and / or kidney failure expressed mielodeprescia, pregnancy, breast-feeding.

Patient interaction

When coupled with a ziklosporinom (especially in patients with impaired kidney) increases the risk of myo with NPVS and other drugs of mielodepressiu-risk leiko- and trombozitopenia. Compatible with allopourinolom and drugs urikozuriceski action. Do effect deprimiruth and simpatomimeticakih funds. Violate zianokobalamina induction. Protivopodagricescuu activity decreased cytostatics (increase the concentration of uric acid), and urine zakislate PP reinforce oschelacivate-inflammatory drugs.

Precautions

Treatment should be carefully gemotologicakim and clinical supervision. When expressed adverse effect from the blood to be lower dosage. The decline in the number of cells less frequency ^ 9 / l, and platelets below 1h10 ^ 6 / l You must stop until the picture Krovi.s caution should appoint a sick elderly with kahexiei, severe violations of the digestive and cardiovascular diseases.

Storage conditions

List A. dry, the dark place at a temperature of no higher than 25 ° C

Shelf life

5 years

The registration

014955/01-2003

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