Sulfinpyrazone

Chemical name

1,2-Дифенил-4-[2-(фенилсу��ьфинил)этил]-3,5-пиразо лидиндион

Gross

C23-H20-N2-O3-S

Characteristics

White or colourless powder, insoluble in water. Rat in ethanol and acetone.

Of drugs

The drugs-gipouriquemicescoe, противоподагрическое . Increases down uric acid by reducing its reabsorbtion in the proximal bone nefrona. As a result of declining education tofusov and reduced povrejdatee of uric acid in the body and reduce the risk of uratnah stones in mochevforodaschei Sisteme.bystro and completely absorbed from the digestive tract. Connectivity plasma protein is 90%. Treated biotransformation in the liver into two active metabolites : парагидроксисульфинп иразона and metabolita sulphide. T_1/2 : sulfinpirazon to three hours, Unit-1 p, sulphide-induced 9-15 p.m. Duration of 4-6 hrs During two days kidneys displayed 45-50% of sulfinpirazon, 25% of sulfinpirazon glukuronida and 10% of other metabolites, about 5% from fecal masses.

Indications

Giperuriquemia, gout.

Restrictions on the use of

There is no information on the safe use of the drug in pregnant and lactating women as well as children.

Contraindications

Hypersensitivity, saying disease stomach and duodenal ulcers (including in history), renal failure, filter disease pathology blood.

Side-Effects

Diarrhoeal phenomenon : nausea, vomiting, pain in the abdomen, diarrhoea; Gastrointestinal bleeding, agranulozitos, lakopenia, thrombocytopenia, anemia, allergic reactions.

Patient interaction

Do the anti, antiagregantov, fibrinolitikov, gipoglikemicakih and protivopodagricakih funds. Alcohol, etakrinova acid tiazidnye dioretiki reduce effectiveness.

Dosing and Administration

Adults : inside after eating at 100-200 mg twice a day, squeezed milk. With good endurance dose can be increased during the week to 800 mg per day. Supporting dose is 100 mg a day.

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