Cocarboxylase

Chemical name

3-[(4-Амино-2-метил-5-пири мидинил)-метил]-4-метил -5-(4,6,6-тригидрокси-3,5-д��окса-4,6-дифосфагекс-1-��л)тиазолий chloride P P'-dioksid

Gross

C12-H19-Cl-N4-O7-P2-S

Characteristics

Liofilizirovannaya dry porous mass gigroskopicnaya white with a low specific aroma, rastvorima easily in the water.

Of drugs

The drugs-kofermentnoe. Is kofermentom thiamine. Along with the protein and magnesium ions is part of the enzyme carboksilaza, catalytic carbauxilirovanie and decarbauxilirovanie alfa-ketokislot (including dofamine acid), facilitates azetil-kofermenta A and regulates carbohydrate exchange.

Indications

Metabolic, respiratory and diabetic acidosis; Kidney, liver, heart (acute, chronic) deficiency; Of a heart rhythm, predinfarktnoe state, myocardial infarction, and diabetic coma hepatic and peripheral neuritis, multiple sclerosis, chronic alcoholism, intoxication pathological processes violating Carbohydrate exchange. The newborn perinatal gipoksica encephalopathy, respiratory distress, pneumonia, sepsis; Other conditions associated gipoksiei and azidozom.

Contraindications

Гиперчувствительност ь.

Side-Effects

Allergic reactions : urticaria, skin elasticity; With the / m introduction hyperemia, itching, swelling at the injection.

Specific guidance

Kocarboksilaza applied mainly in the integrated therapy.

Patient interaction

Do effect and improves the portability of cardiac glycosides.

Dosing and Administration

V / m or / in (struino or drip), with the adult heart diseases 0.05-0.1 g / sut. The course of treatment 15 to 30 days. In diabetes, in / in the 0.1-1.0 g / day (without interrupting normal protivodiabeticescoy therapy) for 5-10 days; In acute kidney or liver failure, intoksikatziah, burns in / in (struino) 0.05-0.15 g three times a day or drip (tentatively rastvoriv 400 ml of 5% glucose solution) to 0.1-0.3 g / day; with peripheral neuritis and spread EMG, in the / m 0.05-0.1 g / day during 1-1.5 Mes.detam 0,025-0,05 g / day for a period of 7 to 15 days. Newborn subilgvalno designate.

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