Ergocalciferol

Chemical name

(5Z,7E,22E)-9,10-Секоэргоста- 5,7,10(19),22-тетраен-3-ол

Gross

C28-H44-O

Characteristics

The white crystalline powder. Nerastvorim in water, soluble in alcohol, ether, chloroform, vegetable oils; Sensitive to the effects of light, oxygen, air, etc. oxidizing factors.

Of drugs

Drugs, the lack of complementary vitamin D governing calzi-fosfornyi exchange. The body is active metabolites vitamin D, in particular calzitriol, easily crossing cell membranes and phones in the cells Organs with special receptors; With the advanced fusion protein (protein binding calcium, collagen, alkaline PHOSPHATASE etc.), and facilitated the flow of calcium through the bowel wall to the blood and then transport in the tissue. Influenced calzitriola bones in the normal cartilage cells in the areas of growth, activated protein synthesis stroma, taking calcium from plasma and its deposition in the form of phosphate, in the kidneys, the necessary conditions for reabsorbtion calcium, sodium phosphate, amino acids, in zitratov proximal bone, with the support normal level of calcium in the plasma and an obstacle excesses paratgormona and fosfaturicescomu Actiou.pri introduction into rezorbiruetsa in distalnom Division small bowel to 60-90% (when gipovitaminose almost completely), the films to elixirs, with the lower income intestine intensity and completeness removals decline sharply. In limfe and plasma vitamin circulates in the hilomikronov and density, which affects the liver, bone, skeletal muscle, kidney, adrenal glands, miocard, jirovu fabric. Treated biotransformation, becoming active metabolites : in the liver in calzidiol (form of transportation), in the kidneys from calzidiola in calzitriol. Excreted with jelchew in intestine, which in part reabsorbiruetsa; Particularly long vitamin D and its metabolites are stored in adipose tissue.

Indications

Rickets, diseases of bones caused by the violation of calcium (osteoporosis, nefrogennaya osteopatia) dysfunction paraszczytovidnykh glands (including tetania), psoriasis, lupus diskoidnaya, some forms of tuberculosis, epilepsy (children receiving phenobarbital or difenin).

Restrictions on the use of

Be wary appoint elderly (due to the potential for haemoglobin), and women over the age of 35 years.

Contraindications

Gipercalziemia, active tuberculosis, gastrointestinal diseases, liver and kidney damage organic heart disease in the decompensation.

Side-Effects

D-gipervitaminoz.

Specific guidance

In appointing vitamin D premature births at the same time to introduce phosphates.

Patient interaction

Toxic effect weakened retinoidami, tokoferolom, ascorbic acid pantotenova acid tiaminom, riboflavinom, piridokshinom.

Overdosing

There D-gipervitaminozom : loss of appetite, nausea, headache, general weakness, irritability, insomnia, fever, changes in the urine analysis, the increase in the calcium content in the blood and urine, calzinoz soft tissue, kidneys, lungs, Sosudov.lechenie : symptomatic.

Dosing and Administration

Inside. For prevention of pregnant and lactating women, children. Dose selected individually.

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