Pyridoxine

Chemical name

5-Гидрокси-6-метил-3,4-пи ридиндиметанол (and as hydrochloride)

Gross

C8-H11-N-O3

Characteristics

White powder melkochristalliceski odourless gorkovato-kislogo taste. Easily soluble in water, it is difficult to alcohol. Under the influence of light in water solutions destroyed.

Of drugs

Drugs, the lack of complementary vitamin B_6. Fosfauriliruetsa and in the form of piridoksalfosfata part of the enzymes catalyzing decarbauxilirovanie and pereaminirovanie. Plays an important role in metabolism triptofana, glutaminova acid zisteina, methionine, as well as in the transport of amino acids through the cell membrane. What to activate fosfaurilaza for education neiromediatorov, gamma-aminomaslana acid, glycine, serotonin. Participates in exchange B_12 vitamin, folic acid, in the synthesis of porphyrins, in the exchange of unsaturated fatty acids. Applies to the activation of metabolic processes in miofibrillah, especially in the fetal heart. Daily demand for adults is 2-2.5 mg, for children from 6 months to 1 year, 0.5 mg, 1-1.5 years, 0.9 mg, 1.5-2 years, 1 mg, 3-4 years, 1.3 mg, 5-6 years, 1.4 mg, 7-10 years, 1.7 mg, 11 to 13 years, 2 mg, for boys 14-17 years old - 2.2 mg, for girls 14 to 17 years is 1.9 mg.

Indications

B_6-gipovitaminos, toxaemia of pregnancy, sideroblastnaya anaemia, hemorrhagic diseases of CNS (parkinsonism low trochaic illness Littl, radikulita, neuritis, neuralgia, Ménière disease), maritime and air disease, arteriosclerosis, diabetes mellitus, and seboreepodobnyy neseborainey dermatitis, herpes zoster, neirodermit, psoriasis, ekssoudativei diates use of the drug tests.

Restrictions on the use of

Ulcers disease stomach and duodenal ulcer.

Contraindications

Гиперчувствительност ь.

Side-Effects

Allergic reactions, the acidity gastric juice.

Patient interaction

The effect of reduced isoniazid, cycloserine, penicillamine. Farmatsevticeski incompatible with vitamins and B_1 B_12. Ters противопаркинсоничес кую levodopa activity.

Dosing and Administration

Inside, for the treatment of IMR adults appoint 80 mg four times a day; Dropped (in / m, / in, c / a) in a daily dose of 150-mg. The duration of treatment is determined by the type and severity of disease. To prevent vitamin deficiency B_6 designate up to 40 mg / sut.

Directory → Metaboliki → Vitamins and the vitaminopodobne → Pyridoxine