Riboflavin

Chemical name

7,8-Диметил-10-(D-1-рибити��)изоаллоксазин (in the form of sodium monofosfata)

Gross

C17-H20-N4-O6

Characteristics

Orange crystalline powder bitter taste, with low specific smell, the light sensitive. It is soluble in water and alcohol. Aqueous solutions are yellow colour.

Of drugs

Drugs, the lack of complementary vitamin B_2 governing окислительно-восстан��вительные processes. Substratno activates synthesis flavinovykh kofermentov, has been working with the ATF is the flavin-mononukleotid and flavin-adenin-dinukleotid involved in the transport of protons and regulation окислительно-восстан��вительных processes. Chemically pure riboflavin and its nucleotides quickly imbibed in the stomach, absorption slowed various inflammatory processes in the gut, disorders of the circulatory system, ahilia, chronic gastritis, enteritis; In infants induction has been slower than in adults. Distribution in the body unevenly : the largest number found in miocarde, liver, kidneys. Provided mainly with urine in an unmodified form; In the normal vitamin content in the body for the day with urine is about 9% imposed dose, and the rest in reabsorbiruetsa bone kidney; With a surplus increased excretion and urine in the color yellow. Eliminations riboflavine improved in the тиреотоксикозе.Играе�� important role in the metabolism, has been involved in the processes of growth. Daily need for an adult is 2.5 mg, with the heavy physical labour, some 3 mg; For children from 6 months to 1 year, 0.6 mg, 1-1.5 years, 1.1 mg of 1.5-2 years, 1.2 mg, 3-4 years, 1.4 mg, 5-6 years, 1.6 mg, 7-10 years, 1.9 mg, 11 to 13 years, 2.3 mg, 14 to 17 years : for boys and 2.5 mg for women - 2.2 Mg.podderzivaet the numerous influences on the morphology and function of the central and autonomic nervous system plays an important role in maintaining the normal functions of visual eyes and in the synthesis of Erythropoietin, hemoglobin. Several more secretornuu the stomach (participates in the formation of hydrochloric acid gastric juice), improves jelchevadelenie facilitates the induction carbohydrate fine leg to be necessary for the maintenance of normal intestinal microflora. Is the glikogenofiksiruta, synthetic, antitoksicski liver, increases sensitivity liver cells to the action of insulin, helps incretii insulin. Normalizes cium level in the blood (hepatitis A).

Indications

Hypothesis and ariboflavinoz exotic and endogenous origin gemeralopia, conjunctivitis, irit, keratit, clouded cornea, cataracts, is not the long-term healing wounds and ulcers, radiation sickness, fatigue, heilit, angular stomatitis (zaeda) glossit, dermatos itching, eczema, neirodermit, fotodermatos, palliative red acne, candidiasis, viral hepatitis A, chronic hepatitis, cirrhosis, a breach of the blood, spru, wasting, anaemia, leukaemia. The preventive measure is to reduce the intake of blood, intensive off and the need for riboflavine (acute and chronic hypoxia, respiratory and cardiac failure, the disease burns, frostbite, malnutrition and protein abundance Carbohydrate nutrition, acute infectious diseases, including in the treatment of antimicrobial means shock gramotricationuyu bowel flora, fototerapia).

Contraindications

Hypersensitivity, stone.

Side-Effects

Violations of view, the functions of the kidneys, allergic reactions.

Specific guidance

The staining of urine yellow.

Patient interaction

Aminazin, imizin, amitriptyline violate (blockade flavinokinaza) inclusion in riboflavine flavin-mononukleotid, флавин-аденин-динукле отид and increase its withdrawal with urine. The combined application with tireoidnami hormone accelerates metabolism. Influenced m-holinoblokatorov increasing intake and bioavailability (by slowing peristalsis of the bowel). Compatible with protivoanemicakimi means antigipoksantami, anabolikami. Prevents or reduces the unwanted effects of chloramphenicol (violation gemopoaiza, optic neuritis). The slowdown tetracycline.

Dosing and Administration

Inside on the 5-10 mg (children 2-5 mg) 1-3 times a day during 1-1.5 months. Daily intake to 50 Mg.v / m-1 ml 1% solution every day for 15 days (children 3-5 days), and then two or three times a week, only 15 to 20 injections. With eye diseases for 0.2-0.5 ml of 1% solution for 10-15 days.

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