Thiamine

Chemical name

3-[(4-Амино-2-метил-5-пири мидинил)метил]-5-(2-гидр оксиэтил)-4-метилтиазо лия chloride

Gross

C12-H17-Cl-N4-O-S

Of drugs

Drugs, the lack of complementary vitamin B_1, metabolicescoe, immunostimulating, antioxidant, ganglioblokirtee. Fosfauriliruetsa form tiaminpirofosfat, which has many effects of thiamine. Since the introduction into the skin mainly in the duodenum and small intestine. Quickly and completely absorbed with the / m injection. Distributed to all tissues. Daily metabolised approximately 1 mg. Daily demand for vitamin B_1 for adult males, ranging from 1.2 to 2.1 mg; For the elderly, 1.2-1.4 mg; For women 1.1-1.5 mg appendix in pregnant 0.4 mg and the nursing 0.6 mg; For the children, depending on age, 0,3-1,5 mg. As a tiaminpirofosfata as many koferment decarboksilaz, participates in the metabolism piruvata, alfa-ketoglutarata and plays an important role in the exchange of carbohydrates. Protects cell membrane from the toxic effects of peroxide oxidation.

Indications

Gipovitaminoz and beri B_1 (including in patients in zondovom nutrition at gemodialise suffering malabsorbtion syndrome), reduced flow vitamin in the body is a violation of intake in the gut, malnutrition, chronic alcoholism, expressed human liver, thyrotoxicosis and increased need for vitamin-pregnancy, lactation, a period of intensive growth; Neuritis, sciatica, nevralgia, peripheral paresis or paralysis atony bowel miocardiodistrofia, Medicine, zoster, psoriasis, eczema, intoxication.

Contraindications

Гиперчувствительност ь.

Side-Effects

Allergic reaction, swelling Kwinke, urticaria, skin itch.

Patient interaction

Ters effect depoliarizuth miorelaksantov (ditilina etc.). Pyridoxine turning down thiamine in tiaminpirofosfat increases allergizatiou. Farmatsevticeski inconsistent (in one sprite) with penicillin, streptomycin, nicotinic acid.

Dosing and Administration

Inside (after delivery) and parenteral. Dose with ingestion is for adults 10 mg 1-3 (5) times a day. Children under the age of three, appointed to 5 mg a day; 3-8 years in the 5 mg three times a day through the day; Over 8 years to 10 mg 1-3 times a day. The course of treatment is usually 30 days. Start injecting encouraged with low doses (up to 0.5 ml 5% or 6% solution), and only with good endurance introduce higher Dozy.v / m adults on 0,02-0,05 g thiamine chloride (1 ml of 2.5% or 5% solution) or 0,03-0,06 g thiamine bromide (1 ml of 3% or 6% solution) once a day, every day. For children to 0.0125 g thiamine chloride (0.5 ml of 2.5% solution), or 0.015 g thiamine bromide (0.5 ml of 3% solution). Exchange-30 injection.

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