Atilpirin

Roman name

Acylpyrin #

The composition and the form of

1 tablet or 1 vodorastvorimaya effervescent tablet contains acetylsalicylic acid 500 mg; blistere in 10 pcs. or aluminium tuba with the plastic cap 15 pcs. respectively, in a carton one blister or 1 tube.

Of drugs

Disinfecting, cough, analgezirutee. Ingibiruet biosynthesis inventory, which affects the gipotalamicakih centres thermal and pain sensitivity. Decreases algogennoe bradikinina effect. Affects processes occurring in the middle of inflammation : reduces the permeability of capillaries, reduces activity gialuronidasy limits energy inflammatory process.

Pharmacokinetics

C_max blood achieved through two hours after injection. Provided mainly urine, mostly in the form of salicylic acid and its kongugatov. T_1/2 2,5-8,5-p-much depends on the dose and urine pH (with a large dose extended to 16-19 h).

Indications

Pain different genesis (stay, stay) and localization (headache, joint, muscle pains, toothaches, pain in the spine, neuralgia, etc.); Hyperthermia with acute respiratory diseases episode nature.

Pregnancy and lactation

During pregnancy (crosses the placental barrier), and breast (enters the mother's milk) can be done only short-term use.

Contraindications

Hypersensitivity, bloody diates surgical intervention (involving significant bleeding), saying the disease stomach and duodenal ulcers, bronchial asthma, gout.

Side-Effects

Diarrhoeal disorders hidden bleeding (including gastrointestinal), Iron-deficiency anaemia of blood, liver damage, necrosis parenhima kidney Rayee syndrome in children, "aspirinova" asthma, allergic reactions.

Patient interaction

Do proximity effect anticoagulants, methotrexate, barbiturates, oral antidiabetics funds sulfonamidov, penitsillinov, tetracycline, and corticosteroid pyrazolone (ulzerogenny) increases plazmaticalkie levels antidepressants; Reduces the sulfinpirazon, spironolakton level NPVS. Skin wrinkles and gistamino- holinolitikov, narcotic analgesics, chloramphenicol and others (a pause 2-3 h between reception inside these drugs). Antatsida, combined increase of atilpirina; Barbiturates, corticosteroids, holestiramin etc. - are weakening. Incompatible with alcohol.

Overdosing

The main sign of intoxication is giperventilatia (Kussmaula breath).

Precautions

With long-term use, there is a need to control cellular composition of blood and the possibility of hidden bleeding from the digestive tract. In appointing people for whom excess of sodium ions contraindications should take into account the existence of sodium in the effervescent tablets.

Dosing and Administration

Inside, during or immediately after eating on the table 1-2. (schipuchuu tablets that dissolve in a small amount of water) 2-3 times a day (but not more than 6 g / day). Children shall be refused : 1 to 6 years in the 150-250 mg; from 6 to 15 years in the 250 mg three times a day. In the acute phase of fever-100 mg / kg / day 5-6 receptions. Противовоспалительны е dose of 3-6 g / day (short).

Storage conditions

table. : List B. In dry the dark place at a temperature of no higher than 25 ° Ctabl.ship. : In dry the dark place at a temperature of no higher than 25 ° C

Shelf life

table. : 2 g.tabl.ship. : 2 grams.

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