Anopirin

Roman name

Anopyrin #

The composition and the form of

1 tablet contains acetylsalicylic acid 400 mg, as well as calcium carbonate 111 mg and glycine 100 mg as a buffer substances; blistere in 10 pcs. , in the box one blister.

Of drugs

Disinfecting, cough, analgezirutee, antatsidne, gastroproteguoe. Inactivate ziklooksigenzu violates synthesis NG prostatziklina and tromboksana. This is a decrease pyrogenic influence at the centre of thermal and sencibiliziruth to the brain, leading to higher thresholds of pain sensitivity. Ingibiruet agregatia platelets (by braking synthesis tromboksana A_2).

Pharmacokinetics

It absorbed in the digestive tract. C_max general salicilata plasma achieved in 2 hours Linking plasma protein-80-90%. Metabolised in the liver metabolites derived from urine.

Clinical pharmacology

The so-called buffer pills reduce the likelihood of undesirable reactions from the blood.

Indications

Pain (headache, dental, muscle, joint, psoas, neuralgia), and the feverish, especially in acute respiratory diseases, arthritis.

Contraindications

Hypersensitivity, bloody diates surgical intervention, with the major bleeding, saying the disease, bronchial asthma, gout.

Side-Effects

Diarrhoeal phenomenon increased bleeding hidden bleeding in the digestive tract, Iron-deficiency anaemia of blood, finger necrosis of the kidney and liver damage, Rayee syndrome in children allergic reactions.

Patient interaction

Do proximity effect anticoagulants, methotrexate, barbiturates, oral gipoglikemicakih, antibiotics, the ulzerogennoe Corticosteroids, pyrazolone reduces dioretikov-level in the blood vitamin C. The increase Anopirina antatsida, substances zakislate urine, combined, PASC, procaine; - Reduce barbiturates, corticosteroids, holestiramin, substances oschelacivate urine. Incompatible with alcohol.

Overdosing

A typical sign-giperventilatia (Kussmaula breath).

Precautions

In a long-term, it was necessary to monitor picture of the blood and the possibility of hidden bleeding.

Dosing and Administration

Inside, tentatively dissolve in a small amount of water on the 800 mg 2-3 times a day, but no more than 6 grams; Children 1 to 6 years, 150 mg, from 6 to 15 years in the 250 mg three times a day. In acute rheumatism-100 mg / kg / day 5-6 receptions.

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