Auranofin

Chemical name

(1-Тио-бета-D-глюкопира��инато)(триэтилфосфин) золота 2,3.4,6-tetraazett

Gross

C20-H34-Au-O9-P-S

Characteristics

Contains 29% metallic gold.

Of drugs

Drugs, the anti-inflammatory, immunodepressivne, antiproliferativoe. Follow-up effects to be fully clarified, however, it is believed that the suppression of cellular immunity to carbon substances monocitami and polimorfnoyadernami leikotitami resulting in numerous oppression and blockade of lysosomal enzymes. Reduces activity sulfgidrilnykh systems and complexes enzimnykh cells and lymphocytes, ensuring ultimately decrease in the concentration of immunoglobulins and rheumatoid factor. At the same time, falling synthesis of collagen and NG. After intake of rats 25%. The blood of up to 60% is associated with malnutrition. The liver is the rapid biotransformation. T_1/2 in the blood of 21-31 day, and in the tissues, 42-128 days. The effect is a 3-4, and sometimes six months. Eliminations : 60% vsosavchegosa products (15% of the dose) excreted with the urine, while the remainder were from faeces.

Indications

Rheumatoid arthritis, psoriaticeski arthritis, Felti syndrome.

Restrictions on the use of

Children's age, breastfeeding.

Contraindications

Hypersensitivity, aplasia bone marrow, a blood exfoliativei dermatitis, enterocolitis, pnevmofibros, pathology kidney Shegrena syndrome, systemic lupus red, lakopenia, vasculita, pregnancy.

Side-Effects

Diarrhoeal phenomenon язвенно-некротически�� disease, gingivit, glossit, gastritis, necrotizing enteritis, enterocolitis, Colitis, pharyngitis, tracheitis, intersticialnaya pneumonia, pnevmofibros, principally syndrome with a massive proteinuriei, holetaz, cholelithiasis, hepatitis, block, hallucinations, seizures apnoea, vaginitis, agranulozitos, thrombocytopenia, anemia, pancitopenia, dermatitis, eozinofilia, allergic reactions.

Patient interaction

Side effects reinforce cytostatics, and gepato- nefrotoksicnae preparations penicillamine.

Dosing and Administration

Inside. Adult initial daily dose of 6 mg once or in two installments. In the absence of effect within six months dose increase to 9 mg / day in 3 admission. In the event of failure of treatment for the next three months preparation repeal.

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