Celecoxib

Chemical name

4-[5-(4-Метилфенил)-3-(три��торметил)-1H-пиразол-1-��л]бензолсульфонамид

Gross

C17-H14-F3-N3-O2-S

Of drugs

The drugs - противовоспалительно е. Yes ingibiruet ziklooksigenzu-2 (TOG-2) and blocks education provospalitionah Pg.pri inside a rapidly absorbed. C_max achieved in 2-3 hours Away particularly rich fats, slowing resorption. The bonding with the plasma protein-97%. Evenly distributed in the tissues, permeates through GEB. Biotransformiroetsa in the liver, with the participation of zitohroma R450 CYP2C9. T_1/2 12-hour general Cl-500 ml / min. Place in the form of active metabolites, mainly through blood, a small number (less than 1%) unchanged zelecoqsiba detected in the urine.

Indications

Rheumatoid arthritis, reactive and sinovit syndrome in osteoartroze.

Restrictions on the use of

Allergic reactions to others and NPVS sulfanilamida, heavy human liver and kidneys, heart failure, saying the disease stomach and duodenal ulcers in the phase of deterioration, pregnancy, age less than 18 years of age and old age.

Pregnancy and lactation

Nursing women on the treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь.

Side-Effects

From the nervous system and sensory organs :> 1% dizziness, headache, weakness, insomnia; 0.1-1% of the uncertainty, in the bell ring, paresthesia, increased anxiety and depression; From the circulatory system and blood (blood, gemostaz) : 0.1-1% arterial hypertension, heart, anaemia; From the respiratory system :> 1% pharyngitis, rhinitis, sinusit, infection upper respiratory tract; 0.1-1% cough, Odyshka.so part of the intestine :> 1% pain in the abdomen, diarrhoea, neuralgia, flatulence, nausea; 0.1-1% constipation, slavery, gastritis, stomatitis, vomiting, the liver, the ACT and ALT; 1% itching, rashes; 0.1-1% urticaria; 1% peripheral oedema; 0.1-1% stiffness in the legs, infections urinary tract.

Patient interaction

Flukonazol increases in the concentration of plasma antatsida reduce intake in the intestine.

Precautions

Older patients with a lower body weight, and weather (light and moderate) liver or heart failure treatment to start with small doses.

Dosing and Administration

Inside, and osteoartroze 100 mg twice daily or 200 mg once a day; Revmatoidnom with arthritis, 200 mg twice a day.

Literature

1. Nasonov Patients Specific inhibitors gli (TOG) -2 resolved and unresolved problems / / Mountain. pharmacology and therapy .- 2000 .- T. 9 .- N 1 .- C. 57-64.2. Peterson W.L., Cryer B. COX-1-sparing NSAIDs, is the enthusiasm justified? / / JAMA 1999 .- .- V. 282-N-20 P. 318.

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