Diflunisal

Chemical name

2',4'-Дифтор-4-гидрокси[1, 1'-бифенил]-3-карбонова�� acid

Gross

C13-H8-F2-O3

Characteristics

The white crystalline powder, nerastvorim almost in the water. Rat in most organic solvents, such as ethanol, methanol, acetone.

Of drugs

Drugs, the anti-inflammatory, analgezirutee, analgesic. Does ziklooksigenzu violates cascade arahidonova acid and reduces emissions. Thus, suppressed ekssoudatus and proliferatius phase inflammation, decreases the sensitivity of pain receptors in the endogenous algogenam and, second, reduced their synthesis. Reduced emissions in gipotalamicescoy field in the area of the thermal teplootdachu increases, leading to a decrease in body temperature. And antiagregaim effect in doses exceeding терапевтические.Посл�� intake of rapidly and completely absorbed from the digestive tract. C_max achieved through normal hours Associated with the plasma protein by 99%. Treated biotransformation in the liver with the formation of active metabolites. T_1/2 is 8-12 hours 80-95% drug excreted news in the form of metabolites, and less than 5% in the active form in the 72-96 hours

Indications

Arthritis, rheumatoid arthritis, arthritis, pain syndrome inflammation genesis, headache pain.

Restrictions on the use of

Breast-feeding (at the time of treatment cease breastfeeding), children's age (safety and efficacy of the children are not identified).

Contraindications

Hypersensitivity, saying disease stomach and duodenal ulcers, bronchial asthma, heart failure, arterial hypertension, oedema, sepsis, systemic lupus red, diabetes, disease, the human liver and kidneys, haemophilia, porphyria, anaemia, pregnancy.

Side-Effects

Npvs-gastropatia : nausea, heartburn, pain in the abdomen, diarrhoea, vomiting, pitting mucosal blood, bleeding; Headache, weakness, drowsiness, insomnia, noise in the ears, impaired vision, loss of liver and kidney bronhospazm, oedema, heart failure, peripheral polineiropatia, thrombocytopenia, anemia, the propensity to bleeding, allergic reactions.

Patient interaction

Do anti-effects, antiagregantov, gipoglikemicakih and side effects mineralokortikoidov, glucocorticoids, drugs gold NPVS. Impact mochegonnah effectiveness. Antatsida slow stripping it from blood.

Dosing and Administration

Adults average daily intake - 0.5-1 grams 1-2 intake of the food. The highest daily intake of 1.5 and

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