Flurbiprofen

Chemical name

2-Фтор-альфа-метил[1,1'-б ифенил]-4-уксусная acid

Gross

C15-H13-F-O2

Of drugs

Drugs, the anti-inflammatory, analgezirutee, cough, antiagregatine. Ingibiruet ziklooksigenzu, resulting in a blocked reaction arahidonovogo cascade and violated synthesis prostaglandines E_2, F_2alfa, tromboksana A_2, prostatziklina. The ingestion rapidly and completely absorbed. C_max in plasma is 1.5 hours Connection with the plasma protein-more than 90%. Metabolised in the liver. T_1/2 about six hours Report the news, largely in the form of metabolites and about 20% in an unmodified form.

Indications

Rheumatoid arthritis, ancylosing spondylitis, acute bursitis, tendonitis, arthritis, distortive osteoarthritis, acute gout, disalgomenorea trauma.

Contraindications

Hypersensitivity, increased losses erosivno-yazvennah blood, bloody syndrome, "aspirinova" triad, liver, kidney and heart failure, arterial hypertension, anemia, pregnancy, breast-feeding (should abandon breastfeeding), a young child.

Side-Effects

Erosivno-azwenne shock syndrome, disease, ezofagit, gastritis, gastrointestinal bleeding, pain in the abdomen, nausea, vomiting, diarrhoea, less frequently, constipation, bloating, increased activity transaminaz liver, jaundice, iron, and Hemolytic aplastic anemia, thrombocytopenia, gematuria, тубулоинтерстициальн ый cases, kidney failure, headache, insomnia, irritability, fatigue, drowsiness, depression, amnesia, tremor, seldom on the mud, parestezi, human consciousness raising uric acid in the serum whose fluid in the body, oedema, eczema, photosensitization, allergic reactions (urticaria, swelling Kwinke, exfoliativei dermatitis, bronhospazm, anaphylactic shock).

Patient interaction

The effect of increasing doses gipoglikemicakie means weakening - dioretiki. Acetylsalicylic acid reduces, and ranitidine increases concentration in plasma. Antatsida slow induction. Increases risk of bleeding in the face of anti proximity.

Overdosing

There headache, diplopia, miozom, declining muscle strength. Depending on the dose observed : more than 1 g, drowsiness, and more than 1.5 grams-initiation of incoming 2.5-4 g-nausea, dizziness, pain in epigastria, more than 4 grams-oppression consciousness until Koma.lechenie : symptomatic.

Precautions

During treatment should monitor the level of hemoglobin, koagulogrammou.

Dosing and Administration

Inside, the food is 50-100 mg three times a day. Rektalno-1 supp. 2-3 times a day supporting dose-1 supp. morning or evening.

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