Ketoprofen

Chemical name

3-Бензоил-альфа-метилб ензолуксусная acid

Gross

C16-H14-O3

Characteristics

White or almost white fine or granular powder, odourless, virtually nerastvorim in water, easily soluble in the organic solvent.

Of drugs

Drugs, the anti-inflammatory, analgezirutee, cough, antiagregatine. Ingibiruet ziklooksigenzu and oppressing synthesis of GHGs. And antibradikininova activity stabilizes lizosomaiona membranes and delaying the release of enzymes that promote the destruction of tissues with chronic bronchitis. Reduces the Cytokines hampered activity Klebsiella. Entering into the skin adequately. Absorption by effects of a "through the liver. The concentration in the blood dozozawisimaya. Easily passes through gistogematicalkie barriers and distributed in the tissues and organs. Biotransformiroetsa in the liver (almost completely). Metabolites derived from urine. Decreases morning constraints and swelling of joints, increases movements.

Indications

Rheumatoid arthritis, Baby spondylitis (ancylosing and psoriaticeski spondilit), gouty arthritis, psevdopodagra, osteoarthritis, rheumatism arthritis (tendowaginit, bursitis, kapsulit) syndrome (post, post-traumatic pain, pain during toxin in the bone), renal kolica, Algodismenorea.gel - neoslojnenne injury (extension and tears tendons and ligaments, bruises muscles, oedema).

Contraindications

Hypersensitivity, kidney and liver failure, hospital disease stomach and duodenal ulcers in the phase of deterioration, "aspirinova" asthma, pregnancy and child. Candles - proktit and proctorragii; Gel-Medicine, eczema, with bruises and wounds (middle).

Side-Effects

Diarrhoeal events (nausea, vomiting, abdominal pain, diarrhoea, flatulence, constipation, anorexia), disease, headache, dizziness, noise in the ears, drowsiness, weakness, visual disorders, kidney function and liver, hyperemia, allergic reactions.

Patient interaction

Do anti effect, unchanged, tiklopidina, Corticosteroids, protivodiabeticakih pills and alcohol weakens - spironolakton, vazodilatatorov peripheral. Increases methotrexate toxicity. Concentration ketoprofena plasma increases in the face of probenecida (oppressing renal excretion).

Precautions

They must not be allowed into the gel on the mucous membranes and eyes. Admission ketoprofena may mask signs of infection. If any of the kidneys and liver to lower doses and closely monitored.

Dosing and Administration

Inside, in / m, / in, rektalno, Mestno.capsula and pills (at the time of delivery), at the beginning of treatment daily dose of 300 mg 2-3 receiving supporting-150-200 mg / Sut.rektalno-1 supp. morning and Vecerom.v / m-100 mg (one bottle) per day over a period of 5 to 10 days, then appoint the interior and / or Rektalno.gel-2 times a day long and gently massaged in sores or painful parts of the body; to the imposition of dry dressing.

Directory → Nenarcoticeskie analgesics, including steroidal and противовоспалительны е means → Ketoprofen