Ketorolac

Chemical name

({+})-5-Бензоил-2,3-дигидр��-1H-пирролизин-1-карбон овая acid (in the form of connection to the two -амино-2-гидроксиметил -1,3-пропандиолом) (1:1)

Gross

C15-H13-N-O3

Of drugs

Drugs, the anti-inflammatory, antiagregatine, cough, analgezirutee. Ingibiruet ziklooksigenzu and oppressing synthesis of GHGs. After the / m of rapidly and completely absorbed. C_max achieved after 50 minutes after a single on / m injection 30 mg at 2.2 µ g / J The on / in Infusion 10mg of the largest plasma (2.4 µ g / ml) is defined in 5.4 min. Equilibrium concentration achieved within days after every six hours The ingestion rapidly and completely absorbed. C_max is, on average, 40 minutes 10 mg at 0.7-1.1 µ g / ml dose of 10 mg. More than 99% is associated with blood protein. The link does not depend on the concentration sossoudistom course. Eliminations comes from biotransformation and renal (mostly) out. In patients with impaired renal excretion is slowing. Its speed is reduced to the degree of kidney function, except for patients with severe renal insufficiency (plasma Cl slightly higher than expected for the degree of kidney damage). Urine found 92% imposed dose in feces 6%. In a multiple Cl ketorolaka does not change.

Indications

Pain syndrome moderate and severe symptoms : chronic pain, pain in the joints and causes the gap ligaments, sprains, strains; Pain in the back and joints.

Contraindications

Гиперчувствительност ь (incl. to aspirin, etc. NPVS), nasal polyps, angioneuroticeski swelling, bronhospazm, bronchial asthma, stomach ulcers and gastrointestinal diseases, a violation of kidney gipovolemia, dewatering, the high risk of postoperative bleeding or incomplete stopping bleeding, the blood, bleeding in the brain, pregnancy, breast-feeding (for the period of treatment needed to stop breastfeeding) young child (up to 2 years).

Side-Effects

Brown mouth, neuralgia, pain in the stomach, nausea, vomiting, diarrhoea, feeling overflow stomach pepticalkie ulcer, gastritis, the liver, flatulence, constipation staining black bar, rektalnoe bleeding, stomatitis, headache, paleness, dizziness, anxiety, depression, drowsiness, fatigue, sweating, swelling, despnoe, bronchial asthma, the taste and sight, vazodilatation, increases urination, oliguria, glomerulonefrit, principally syndrome, acute renal failure, mialgia, urticaria, itching, purpura, pain at the injection.

Patient interaction

Incompatible with drugs lithium pentoksifillinom, probenecidom, antikoagulyantami (in high doses), etc. NPVS. Impact dioreticeski furosemida effect to be associated with normovolemiei. Together with the use of ACE inhibitors has increased the likelihood of kidney function.

Overdosing

Symptoms (for a single) : pain in the abdomen, nausea, vomiting, giperventilatia, a chronic ulceration and / or erosivnogo gastritis, the cold water.

Precautions

The caution used in the human liver, kidneys, bone marrow, liver erosivno-yazvennah in blood disorder, congestive heart failure, bronchial asthma, rheumatoid bronhoobstruguom in history, polipoze nose, angioneuroticescom oteke. Patients with breach blood clotting appointed, but always with control of platelets, especially important for postoperative patients requiring careful hemostasis. Possible appearance in the treatment of sleepiness, dizziness, insomnia or depression requires caution in the classroom potentially hazardous activities that require increased attention and psychomotor speed reactions (drive vehicles).

Dosing and Administration

Inside, in / m, / with children only in Russia. Dose picked individually, taking into account the extent controlling pain. Under dose of 10-30 mg, a factor of up to 4 times a day (every 6-8 hours). The maximum daily dose for older patients is 60 mg. Solution for Injection appointed / m or / as for the treatment of acute and severe pain for a period of not more than five days, the children - 2 days. Pill use no more than 7 days.

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