Lornoxicam

Chemical name

6-Хлор-4-гидрокси-2-мети л-N-2-пиридил-2H-тиено[2,3- e]-1,2-тиазин-3-карбоксам ид 1,1-dioksid

Gross

C13-H10-Cl-N3-O4-S2

Of drugs

Drugs, the anti-inflammatory, analgezirutee, противоревматическое . Indiscriminately ingibiruet ziklooksigenzu (TOG-1 and TOG-2). Impact products NG lakotrienov affects the mucous membrane of the stomach, the platelets and kidney bloodstream. Oppressing release active forms of oxygen kininovu Sistemu.pri ingestion rapidly and completely absorbed, bioavailability is close to 100%. Time to C_max is about two hours (with the / m, a 15 min). The plasma virtually all contact with the squirrels. In gidrauxiliruetsa liver and becomes a pharmacologically active metabolite. T_1/2 - 4h About 30% return rate with urine, mostly in the form of metabolites and the remainder from Jelchew.okazavaet impact mainly on ekssoudativuyu and proliferativuyu phase inflammatory response. In appointing sick Rheumatoid Arthritis has expressed analgezirutee action reduces the morning constraints joint Ritchie index, the number of vospalennah and painful joints; For a number of patients reduces Monday.

Indications

Arthritis : RA, psoriaticeski, acute gouty, infectious; Systemic lupus red (light with a sustave syndrome without defeat kidney), sinovit jet in the deforming osteoartroza, acute illness, koreshkovy syndrome with osteochondrosis, ishialgii; Pain : Falun, dental, and the postoperative posttravmatical.

Contraindications

Hypersensitivity, severe bleeding from the intestine, saying the disease stomach and duodenal ulcers, including in history, prostaglandinova bronchial asthma, inflammatory bowel disease, lakopenia, thrombocytopenia, the liver and kidneys, long cardiac failure, severe arterial hypertension, pregnancy, breast-feeding (at the end of treatment), children and youth (under 18), and old age.

Side-Effects

Nausea, vomiting, stomachache, indigestion, flatulence, diarrhea, dry mouth, reduced appetite, gastritis, ezofagit, erosivno-azwenne defeat mucous membrane of stomach and bowel bleeding from the stomach, active bleeding, the effects on the liver, dizuria, declining clubockova filtering, acute renal failure, intersticialny jade, finger necrosis, headache, dizziness, drowsiness, depression (or initiation) arterial hypertension, tachycardia, the delay sodium and water, peripheral oedema, drugs, sweating, lakopenia, thrombocytopenia, aseptic meningitis, skin rashes, the reactions at the seat of (hyperemia, pain).

Patient interaction

Side effects from the stomach down misoprostol. Other NPVS increase the risk of side effects, the indirect combined-bleeding. Increases gipoglikemicescuu derivatives activity sulfonylureas. Ters dioreticeski effect and increases nefrotoksicnosti dioretikov reduces gipotenziveh-products. Reducyruet kidney Cl digoxin. Increases plasma concentration of lithium products. Against the backdrop of increasing zimetidina lornoxikama level in the blood.

Overdosing

Symptoms : increased side effects of the central nervous system and digestive tract, the AD, cardiac and / or acute renal Nedostaternsti.lechenie : washing stomach, the appointment of activated carbon, monitoring and maintenance of vital functions. Dialysis ineffective.

Precautions

In anamnesticeskih guidance on erosivno-azwenne defeat lornoxikam blood can be used only in conjunction with H_2-blokatorami inhibitors and proton pump. In the long admission requires regular monitoring AD (especially in patients with arterial hypertension), peripheral blood clubockova filtering transaminaz level. Be wary appoint older and depleted patients. Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, the food with sufficient fluid in / m, / 386/1989 Inside, in the initial dose of 16 mg, with a gradual increase in the maximum dose on the first day to 32 mg; Then to 8 mg twice a day. For acute edema controlling pain (lumbago, podagrica attack, post-traumatic pain), in / for a period of 15 s, or / m, the dose of 16 mg (solution are ex tempore, breeding contents bottle in 2 ml of water for injection).

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