Meloxicam

Chemical name

4-Гидрокси-2-метил-N-(5-м��тил-2-тиазолил)-2Н-1,2-бе нзотиазин-3-карбоксам��д 1,1-dioksid

Gross

C14-H13-N3-O4-S2

Of drugs

Drugs, the anti-inflammatory, analgezirutee, analgesic. Yes ingibiruet ziklooksigenzu-2, regulates the synthesis of GHG (including in the middle of inflammation). It absorbed. Exit concentration on the plateau occurs in 3-5 days. 99% circulates in the blood in the form of protein. Passes through gistogematicalkie barriers enters sinovialnuu liquid. Treated biotransformation (mostly oxidized) with the formation of active metabolites. Only 5% of the daily dose excreted unchanged to (through the intestine). Return with faeces and urine in equal proportions. T_1/2 is 20 hours Plasma Cl decline in old age.

Indications

Rheumatoid arthritis, osteoartrita, arthritis and other inflammatory and degenerative diseases of joints, accompanied by sore syndrome.

Contraindications

Гиперчувствительност ь (incl. NPVS to other groups), saying stomach illness being increased, severe liver or terminal kidney failure, pregnancy, breast-feeding (at the end of treatment), adolescence (15 years).

Side-Effects

For part of the intestine : neuralgia, nausea, vomiting, stomachache, ezofagit, gastroduodenale ulcers, constipation or diarrhoea, Meteorizm.so the nervous system and sensory organs : dizziness, headache, ringing in the ears, Sonlivosti.prochie : oedema, the AD heartbeat, increased creatinine and / or urea serum, anaemia, lakopenia, thrombocytopenia, photosensitization, allergic reaction (rash, itching, bronhospazm, urticaria).

Patient interaction

It increases the risk of bleeding in the face of anti-proximity, tiklopidina, heparin, trombolitikov. Increases lithium concentration in plasma. Do methotrexate toxicity (zitopenia), cyclosporine (nefrotoksicnosti). Reduces effective IUDs, antigipertenziveh drugs.

Overdosing

Symptoms : increased by Effectov.lechenie : washing stomach and symptomatic therapy, the introduction holestiramina to accelerate breeding.

Precautions

To apply caution in bronchial asthma, polipozna rinosinusopatii, BCC reduced and the reduced renal white in the face of dehydration, congestive heart failure, cirrhosis of the liver in patients older. In patients with increased risk of side effects are treated with doses of 7.5 mg. In the terminal stage renal failure in patients in dialysis dose should not exceed 7.5 mg / day. In the candles should not be used in inflammatory diseases of the rectum and rectalnah artistic methods in history.

Dosing and Administration

Inside, at the time of delivery, not liquid, in the dose of Seven mg once a day. Rektalno one candle (15 mg) a day. The maximum daily dose of 15 mg.

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