Mesalazine

Chemical name

5-Амино-2-гидроксибенз��йная acid

Gross

C7-H7-N-O3

Of drugs

The drugs - противовоспалительно е. Ingibiruet synthesis NG inhibits chemotaxis, and degranulatia phagocytosis of Klebsiella, the secretion of immunoglobulins CD4 has antioxidant Swoystwami.tabletki (kishechnorastvorimae) are dissolved in thin inserted through silica mines, fully diluted through 165-225 min after administration. In ileuse of tablets normally 15-30% mesalazina, in the thick of atherosclerosis-60-75%, in the blood of up to 10%. The concentration of plasma low-after taking 250 mg C_max is 0.5-1.5 g / J The membrane lining the bowel and liver forms N-ацетил-5-аминосалици��овую acid. Linking mesalazina with plasma protein about 40% metabolita - 75-83%. In Rectal giving daily urine found 10-30% dose. T_1/2 mesalazina 0.5-1.5 h, N-ацетил-5-аминосалици��овой acid-C.effectiven 5-10 in the treatment of colitis, ileita with ulcerative disease, for the prevention of acute ulcerative colitis in patients with �иперчувствительност��ю sulfasalazino to differ reasonable tolerance (even with the dose of 4.8 g / day comparable to the one placebo). Reduces the risk of relapse in ulcerative disease, especially in patients with ileitom and by the length of the disease.

Indications

Inflammatory bowel disease (Baby Ulcerative Colitis, ulcerative disease), in the deterioration and preventing their recurrence.

Contraindications

Гиперчувствительност ь (including from other derivative salicylic acid), expressed human liver and kidney diseases of the blood, bloody diates, saying disease stomach and duodenal ulcers, pregnancy, breast-feeding (at the end of treatment), breast age (up to 2 years).

Side-Effects

The feeling of discomfort, abdominal pain, nausea, bloating, frequent craving for urinating, worsening gemorroi, hyperthermia, grippopodobnyy deficiency syndrome and severe lactose (cramps, bloody diarrhea, fever, headache, rash), fatigue, drug volchanochnopodobnyy syndrome, arthralgia, alopecia, infants, raising transaminaz, alkaline phosphatase, creatinine, urea nitrogen, allergic skin rashes.

Patient interaction

Do ulzerogennosti glucocorticoids, methotrexate toxicity, gipoglikemiceski effect derivatives sulfonylureas, гипопротромбинемичес кий - anti. Wrinkles zianokobalamina removals. Ters activity furosemida, spironolakton, rifampitina.

Precautions

Before, during (1-2 times a month), as well as after treatment (every three months) should monitor the peripheral blood levels of urea, creatinine, total urine. Suspects of the syndrome of acute untreated mesalazin must be eliminated. However, it should be borne in mind that the syndrome of acute untreated in some cases it was difficult to distinguish from severe acute inflammatory bowel disease.

Dosing and Administration

The inside is not liquid, squeezed of water : adults, as the on-1 g four times a day supporting dose of 500 mg three times a day with nonspecific yazvennom kolite and 1 g four times a day, with a crown; children over the age of two years, 20 to 30 mg / kg / day in a few receptions. The plight of over daily dose can be increased to 3-4 grams, but not more than 12 weeks. Rektalno (after emptying the rectum) : With proktite, proktoshigmoidite and left yazvennom kolite adult for one supp. 1-2 times a day. In a drug-mikroklizma 60 g suspension once a day, at night.

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