Nefopam

Chemical name

3,4,5,6-Тетрагидро-5-мети��-1-фенил-1Н-2,5-бензокса��оцин (and as hydrochloride)

Gross

C17-H19-N-O

Of drugs

The drugs-analgezirutee. Affects dofaminove, norarenalinove and serotoninove receptors in the brain. Suppress notsytseptivei sgibatelny reflex; Removes pain and vomiting in the aftercare period; Impedes development oznoba as side effects with on / in a amfoteritina In patients with systemic fungal infections in the face of cancer pathology. The on / in the introduction effect begins in the first 30 seconds, and reaches a peak in 15 to 20 minutes; Duration depends on the dose.

Indications

Pain syndrome varying etiology and intensity, including after trauma and surgery, anesthesia for childbirth, generalized muscle drugs, prevention oznoba as side effects other drugs (amphotericin B).

Contraindications

Hypersensitivity, epilepsy, pregnancy.

Side-Effects

Nausea, drowsiness / insomnia, anxiety, rapid heartbeat, sweating, the lack of view.

Precautions

Avoid drug supplies a host of diseases and conditions involving high sudorojna willingly. During treatment nursing mothers should stop breast-feeding. Do not drive vehicles and occupy other potentially hazardous activities that require greater attention.

Dosing and Administration

Inside, in / m, / 386/1989 For heavily moderately expressed controlling pain inside, in the dose of 60 mg three times a day, the lack of efficiency and good endurance, and 270 mg / day; With greater intensity of pain during childbirth and the postnatal period, dropped to 20 mg three times per day, maximum daily dose of 120 mg. For Then-20 mg in / m one for 15-20 min before surgery or painful procedures. Prevention oznoba with on / in Infusion amfoteritina B-15 minutes before the end of 0.3 mg / kg / m.

Literature

1. Guirimand F., Dupont X., Bouhassira D. et al. Nefopam strongly depresses the nociceptive flexion (R (III)) reflex in humans / / Pain-1999 .- V. 80-N-1 P. 399-404.2. Rosa G. et al. Efficacy of nefopam for the prevention and treatment of amphotericin B-induced shivering / / Arch. Intern. Med-1997 .- V. 157-P. 1589-1592.

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