Niflumic acid

Chemical name

2-[[3-(Трифторметил)фени л]амино]-3-пиридинкарб��новая acid

Gross

C13-H9-F3-N2-O2

Of drugs

Drugs, the anti-inflammatory, analgesic, analgezirutee, antiagregatine. Decreases capillary permeability, lizosoma stabilizes and the barriers to entry in zitoplazmu in vnecleterne space lysosomal enzymes down a makroer 4a27e gicakih phosphate (especially ATF). Ingibiruet ziklooksigenzu and oppressing synthesis NG suppresses agregatia platelets. The ingestion quickly and adequately absorbed, C_max recorded in 2 hours Linking protein up to 90%. In biotransformiroetsa liver into two inactive derivative : 5-gidroxiniflumova acid and 4-gidroxiniflumova acid; Both metabolita contact glukuronova acid. T_1/2 - 4-5 pm Write mainly kidneys, partly in an unmodified form.

Indications

Osteoarthritis, rheumatoid arthritis, ancylosing spondylitis, gouty arthritis, bursitis, tendonitis epikondilit, injury bones was adneksit, parametrit, sinusit, pharyngitis, laringit average otitis, throm superficial veins, lumbago, extraction of a tooth, pain syndromes after surgical and акушерско-гинекологи��еских interventions.

Contraindications

Hypersensitivity, saying disease stomach or duodenal ulcer in the phase of growing expressed human liver or kidney; Availability cancer, eczema, wounds at the site of the alleged cream, pregnancy, age child (up to 13 years).

Side-Effects

Diarrhoeal disorders, anorexia, melena, tranzithornoe increase in the blood transaminaz liver, bone fluorosis (after several years of treatment of high doses); Local using creams : hyperemia, itching, pain, rash.

Patient interaction

Do proximity effect anticoagulants, glucocorticoids, the gipoglikemicescoe derivatives sulfonylureas. Tiklopidin increases (mutually) antiagregatinuyu activity.

Precautions

There are encouraged to nominate at the same time as metotrexatom drugs or lithium.

Dosing and Administration

Inside (during or after delivery), Local. Adults - 1 caps. 3 times a day for children over the age of 13 years, 2 caps. per day; Course-no more than 4-5 days. Locally : 5-10 cm cream three times a day.

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