Salicylamide

Chemical name

2-gidroksibenzamid

Gross

C7-H7-N-O2

Characteristics

The white crystalline powder. It is soluble in water, soluble in alcohol.

Of drugs

Drugs, the anti-inflammatory, analgezirutee, cough, antiagregatine. Does ziklooksigenzu violates metabolism arahidonova acid reduces the amount of GHGs and tromboksanov body in the middle of inflammation, suppresses ekssoudativuyu and proliferativuyu phase воспаления.Анальгези��ующее is the indirect reduction of biogenic amines with algogennami properties and the increase in the threshold of pain sensitivity IL1 apparatus. Relative concentration PGI_2 (prostatziklina) for a reduction in the number of tromboksanov has antiagregatine Actie.bystro and completely absorbed in the digestive tract. Connectivity plasma protein high. C_max-in 1-2 hours Treated biotransformation in the liver with the formation of inactive azetilirovannah metabolites. T_1/2 6-8 hours Excreted in the kidneys in the form of metabolites.

Indications

Rheumatoid arthritis, arthritis, ancylosing spondylitis, gout, bursitis, tendowaginit, headache, disalgomenorea, revmocardit.

Restrictions on the use of

Pregnancy. Breast-feeding at the time of treatment should be discontinued.

Contraindications

Hypersensitivity, saying disease stomach and duodenal ulcers, Ulcerative Colitis, bronchial asthma, heart failure, oedema, hypertension, haemophilia, the gipokoagulie, disruption of the liver and kidneys, hearing impairment, spinal vestibular apparatus.

Side-Effects

Npvs-gastropatia : pain in the abdomen, nausea, vomiting, heartburn, diarrhea; Bleeding : gastrointestinal, desneve, uterine, gemorroidale; Bronhospazm, cardiac failure, oedema, hypertension, headache, dizziness, hearing impairment, noise in the ears, disruption of the liver and kidney agranulozitos, lakopenia, anaemia, allergic reactions.

Patient interaction

Do anti activity, antiagregantov, fibrinolitikov, as well as side effects and mineralo- glucocorticoids, estrogen, and gepato- nefrotoksicnah funds. Reduces the gipotenziveh and mochegonnah funds. Antatsida and holestiramin reduce removals.

Dosing and Administration

Inside, after delivery of 0.25 grams of 2-3 times a day, squeezed of water.

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