File

Chemical name

8-Хлор-1-метил-6-фенил-4H- [1,2,4]триазоло[4,3-а][1,4]бе нзодиазепин

Gross

C17-H13-Cl-N4

Characteristics

White or white with blue polka melkochristalliceski powder. Nerastvorim in water and poorly soluble in alcohol.

Of drugs

Drugs, the anxiolytic, sedative, miorelaksirutee (central). Communicating with benzodiazepinovmi and Gamkergicakimi receptor is braking limbic system, cheeks, hypothalamus, polisinapticakih spinal reflexes. The ingestion C_max-by 1-2 h, 80% is associated with plasma proteins. T_1/2 - 1630 Reappointment after an interval of less than 12 hours can lead to the cumulation. Metabolism in the liver. Excreted in the kidney.

Indications

Neuroses accompanied by a sense of fear, worry, anxiety, insomnia, withdrawal syndrome in patients with alcoholism and drug addiction.

Restrictions on the use of

Otkratougolnaya glaucoma, chronic kidney and / or liver failure, alcoholic liver failure. Be wary appoint sick profession which requires more attention and speed of reaction.

Contraindications

Hypersensitivity, acute liver disease and kidney problems, infants, pregnancy.

Side-Effects

Drowsiness, dizziness, unstable gait, nausea, constipation, dismenorea, reduced libido, skin disease, addiction, syndrome "lifting."

Patient interaction

Enhance the effect of alcohol, and neirolepticakih pills of narcotic analgesics.

Dosing and Administration

Inside, the initial dose for adults, 0.25 mg three times a day, with good endurance (if necessary) to increase dose every 3-4 days. The maximum daily intake, 3-4 mg.

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