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Atarax

See also Hydroxyzine

Roman name

Atarax

Characteristics

Is difenilmetana derivatives.

Pharmacokinetics

Rapidly absorbed from the digestive tract (in the form of tablets or syrup) reaching S_max in plasma in about two hours after taking the inside. More concentrated in the tissues than in the plasma. The distribution rate is 13-19 litres / kg of the adults and 16 l / kg in children. Penetrates the GEB and placenta accumulating more in fetalnah tissues than in the parent. Metabolised in the liver. The metabolite (45%), cetirizin is expressed N_1-blokatorom. Only 0.8% of drug output unchanged to the kidneys; T_1/2 depends on the age and equal to 160161 in children aged 2-10 years, 20 hours of the adults and 29 hours for the aged and elderly patients. The total Cl is 32 ml / min of children and 10 ml / min in adults and elderly patients. Antigistaminny effect appears in about one hour after taking inwards sedative-by 10 minutes after administration of liquid forms and from 30 to 45 minutes after taking the tablets. In overdose conventional ways metabolism can be overloaded and biotransformation is otherwise. In patients with liver diseases T_1/2 may be extended to 37 hours and antigistaminny effect - extended to 96 hours

Farmakodinamika

The drug has also antiholinergicakim, inflammatory, simpatoliticakim, bronhorasshiratm and protivorvotnam action significantly reduces the skin in patients krapiwnica, eczema and Dermatitom.pri long admission there has been the syndrome, and the deterioration of cognitive functions. Not valeno mutagennogo and cancer-causing.

Clinical pharmacology

In appointing gidroxizina during labor activity in the newborn was arterial hypotension, the motion activity and clauniceskie convulsions, delay urination and signs hypoxia, CNS depression.

Indications

Adults, mild anxiety, arousal, feelings of tension, irritability, and neurological and mental (generalized anxiety and the adaptation), and somatic diseases, as well as in chronic alcoholism, alcohol dependency and its attendant symptoms Vozbujdenia.v a sedative in the period премедикации.Симптом��тическая laser therapy.

Pregnancy and lactation

They are generally not recommended during pregnancy, during childbirth and breastfeeding.

Contraindications

Гиперчувствительност ь any of the components of the drug, cetirizin, aminofillino or etilendiaminu, porphyria. They are generally not recommended during pregnancy, in the period of birth and breast-feeding.

Side-Effects

Weak expressed, sweet and usually disappear in a few days from the beginning of treatment or after a decrease in dose. Linked mainly to oppression or CNS paradoxical CNS stimulation, antiholinergicescoy activity or reaction гиперчувствительност и.Антихолинергически�� effects : dry mouth, the delay urination. bar, a violation ccomodation rare, and mostly in older patients. Can drowsiness, weakness, especially at the beginning of drug treatment (if the effects do not disappear in a few days from the beginning of therapy, the drug dose should be reduced). Also there were headache, dizziness, increased sweating, blood gipotenzia, tachycardia, allergic reactions, nausea, fever, change in the functional samples of the liver, bronhospazm. Clinically significant respiratory depression in the appointment of the recommended doses have been noted.

Specific guidance

Avoid alcohol reception during the Lechenia.pri allergologicakih tests treatment should be discontinued 5 days before the study.

Patient interaction

Potenziruet dampening effect on the central nervous system narcotic analgesics, barbiturates, tranquilizers, sleeping-, alcohol (to be selected individual dose). Avoid joint appointment with MAO inhibitors and antiholinergicakimi средствами.Препятств��ет Development pressonego effect adrenaline, protivosudorojna fenitoina activity, action and betagistina antiholinesteraznah Preparatov.ne effect change atropine, belladonna alkaloids, digitalisa, gipotenziveh funds N_2-antigistaminnah funds. Ters side effects from the stomach and theofillina H_2-agonistov.avletsa inhibitor R450 2D6 and in high doses can interact with the CYP2D6 substrates. Inhibitors liver enzymes can potentially increase concentration in the blood (gidroxizin metabolised in the liver).

Precautions

Be wary of during the drivers of vehicles and people skills relate to the high concentration of Vnimania.s caution appoint people who are vulnerable to the effects sudorojnam suffering from glaucoma, overdetermination of prostate cancer, difficult urinate, zaporami, myasthenia gravis, brain, with a propensity to cardiac arrhythmia or an protiwaritmicescie drugs. Older patients beginning treatment with half the therapeutic dose. Together with the appointment of other means, oppressive central to amend dose. Patients with kidney or liver patients suffering from moderate expressed or severe liver failure, the dosage must be уменьшена.Инъекционн��е form products are designed only for the / m introduction and should not be introduced into / in, in / a, or c / GMT When the / m a need to ensure that the needle is not named in a receptacle; To get under the skin drug may damage tissue.

Storage conditions

List B. In dry place at a temperature below 25 ° C

Shelf life

5 years

The registration

011405/02-1999

The drug forms

Pill-white, long coated films coated with Kołki two Storon.rastvor injection-transparent colourless Rastvor.sirop-clear solution.

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