Bromazepam

Chemical name

7-Бром-1,3-дигидро-5-(2-пи��идинил)-2H-1,4-бензодиаз епин-2-он

Gross

C14-H10-Br-N3-O

Of drugs

Drugs, the anxiolytic. Decreases emotional tension, anxiety, fear, anxiety, it was sedativo-snotvornyi, protivosudorozhny and central miorelaksiruty Effecta.posle intake of rats rapidly and comprehensively C_max already achieved in 1-2 hours Bioavailability is 84%. In the blood of 75% is associated with malnutrition. Treated микросомальному oxidation (N-деалкилирование, алифатическое гидроксилирование) and is 3-гидроксибромазепам and 2 (2-амино-5-бромо-3-гидроксибензоил) -пиридин; The latter as substrates by the action глюкуронилтрансфераз ы become glukuronida. T_1/2 - 10-12 hours may increase slightly in patients senile age. Return with urine, mostly in the form of kongugirovanah metabolites.

Indications

Neuroses and Psychopathy (accompanied by phobias, anxiety, stress), insomnia (with the fear of nervousness), the functional psychosomatic disorders cardiovascular (псевдостенокардия Arterial Hypertension emotional genesis), respiratory (гипервентиляция, difficulty in breathing, shortness of breath), Gastrointestinal (irritation syndrome natural bowel), disorders (frequent urination, дисменорея systems), psychogenic headache and Medicine, премедикация.

Contraindications

Гиперчувствительност ь (including from other benzodiazepines), drug or alcohol dependency, male, pregnancy, breast-feeding (for the period of treatment should be discarded).

Side-Effects

Headache, dizziness, drowsiness, weakness, the concentration, slow mental and motor reactions weakening memory initiation, aggressiveness, fear, sleep disturbance, hallucinations, ataxy, muscle weakness, suicidal tendencies, dry mouth, increased appetite, nausea, diarrhoea, disruption of the liver and kidneys, arterial hypotension, lower libido, changing picture peripheral blood.

Patient interaction

Effect increase neiroleptiki, tranquilizers, antidepressants, narcotic analgesics, anaesthetics, alcohol.

Overdosing

Symptoms : muscle weakness, deep sleep, paradoxical agitation coma, арефлексия, oppression cardiac and respiratory activity stops дыхания.Лечение : washing stomach, the control of vital functions IVL, the maintenance of cardiovascular activity. As an antidote specific antagonist use benzodiazepines - flumazenil (anexat).

Precautions

People aged patients weakened by AIDS and children shall smaller doses. The paradoxical reactions (acute arousal, anxiety, insomnia and hallucinations) requires the preparation. Patients must be warned that in the 4-6 hours after taking large doses they should refrain from potentially hazardous activities that require greater attention and rapid physical and mental reactions. The lower dose gradually, as risk of the syndrome, with the sharp lift preparation.

Dosing and Administration

Inside at night 1.5-3 mg, if necessary, and 6 mg may designation of additional amounts (in the days of 1.5-3 mg 1-2 times). The hospital until 12-18 mg / day for the reception 3-4 (lower daily doses are reducing daily admission).

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