Diazepam nikomed

Roman name

Diazepam Nycomed

The composition and the form of

1 tablet contains diazepam 2 or 5 mg, in bottles of 10 pcs. or blistere 10 pcs. , in the box one blister.

Pharmacokinetics

Almost completely absorbed from the digestive tract and easily permeates through the GEB. Step it is a 15-30 min after administration. C_max plasma is a 0.5-1 h after administration. T_1/2 of children and adults, 20-45 hrs, in newborns it can be as low as 100 hours Linking blood plasma is 96-98%. Diazepam is metabolized in the liver with the formation of active metabolites. Gidrauxilirovanne metabolites are in the form of glukuronidov kidneys. The readmission of preparation is preferable.

Indications

The anxiety and distress, chronic neurotical anxiety, acute stress seetuatinaya anxiety, sleep disturbance, the state of abstinence, and predeliri deliri caused by alcohol or drugs, Spasticity, schizophrenia, convulsions, premedikation combined analgesia with bronho- and gastroskopia, liver biopsy.

Pregnancy and lactation

Contraindicated in pregnancy (I and III trimenon). At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, acute alcohol and sedatives, movements during sleep, male, depression, liver and kidney failure, acute respiratory distress.

Side-Effects

Muscular weakness, drowsiness, weakness, reduced mental and motor activity ataxy, depression, amnesia anterogradnaya violation of consciousness, mental paradoxical reaction, hypotension, tolerance, mental and physical dependence, dry mouth, dizziness, reduced libido, allergic reactions.

Patient interaction

Alcohol, hypnotics, analgesics, drugs, neiroleptiki (especially at high doses), tranquilizers, antidepressants, MAO inhibitors, anti, antihistamines drugs clonidine and opioids increased sedative effect; Theofillin weakens sedative and psihomotornyi effect. Zimetidin, omeprazol, estrogenic oral contraceptives, treating the increasing concentration in plasma.

Overdosing

6.4.3.1.2 consciousness, breaking into a coma. A госпитализация.Специ��ическим is the antidote flumazenil.

Precautions

Lifting after prolonged treatment should be carried out gradually to the lowest dose Nedelu.ne should be applied in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. Do the alcohol within 24 hours after application.

Dosing and Administration

Inside, in conditions of anxiety and distress for adults 2-5 mg 1-3 times a Sutki.detam : 7-16 years in the 2-4 mg three times a day; To 7 years in the 1-2 mg three times a day. Older and patients with impaired kidney-2 mg 2-3 times a Sutki.pri spastic conditions for 5-15 mg / sut. The short course, in some cases, it may be necessary to long-term care insurance, but under strict control.

Storage conditions

At room temperature

Shelf life

5 years

The registration

011583/01-1999

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