Grandaksin

Roman name

Grandaxin

Pharmacokinetics

The ingestion quickly and almost completely absorbed from the digestive tract. C_max achieved in 2 hours, and then the concentration monoeksponencialno lowered. T_1/2 6-8 hours Active metabolites are formed. Displays are mostly (80%) with urine in the form of kongugatov glukuronova acid, 30% excreted stomach. Not koumouliruet.

Clinical pharmacology

Anxioliticeski effect is not accompanied by miorelaksaciei. No impact on the speed and the speed of response, it is drug addiction. Is "Daytime" anxioliticom.

Indications

Neuroses and neurozopodobne condition; State, accompanied by emotional tension wegetativei disorders, mild fear, apathy, decreased activity spirits; Reactive depression with moderately expressed psihopatologicakimi symptoms, post-traumatic stress disorder, mental disorder adaptation, menopause and postcastrationny syndromes (alone or in combination with hormonal PP), pre syndrome, cardialgia (in the form alone or in combination with other drugs), deliriosnoe status (for the lifting of the institution and vegetative symptoms), chronic alcohol syndrome and alcohol tests, male, miopatia, neurogenic muscle atrophy and other diseases with secondary neurotic symptoms, in which protivopokazana anxiolitiki with the expressed miorelaksirutm action.

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь to benzodiazepine - psychosis Psychopathy and with the expressed desire of motor excitation, aggressiveness or deep depression, asthma respiratory distress, I trimester of pregnancy, breast-feeding.

Specific guidance

If you have an allergic reaction or serious violations of sleep reception should be discontinued. In order to prevent disorder sleep last admission preparation should be done not later than 16 hours

Patient interaction

Metoclopramide may accelerate the onset of effect.

Storage conditions

List B. The temperature 15-25 ° C

Shelf life

5 years

The registration

013243/01-2001

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