Hydroxyzine

Chemical name

2-[2-[4[(4-Хлорфенил)фенил метил]-1-пиперазинил]э��окси]этанол (as dihydrochloride or embonate)

Gross

C21-H27-Cl-N2-O2

Производное дифенилметана.Derived difenilmetana.

Of drugs

Drugs, the sedative, anxiolytic. Oppressing activity subcorticalnah some of the central nervous system and it is blocking the central and m-holino- H_1-gistaminove Retseptora.harakterna expressed sedative effect and moderate anksiolitical activity. It has a positive impact on cognitive ability, improves memory and attention. It is psychological dependence and addiction in the long admission there has been the syndrome. Has also antiholinergicescoe, skin, antigistaminnoe effect. Relaxes smooth muscles has bronhodilatirutm and analgezirutm effect has protivorvotnoe and miorelaksirutee operation and moderate ingibirutee impact on jeludocnuu secretion. Decreases in the skin krapiwnice, ackzeme, Acne and Dr.sedativei effect usually is a 10-45 minutes after taking the inside (depending on the drug form), antigistaminny through one hour after taking the inside. In patients with liver diseases antigistaminny effect can last for up to 96 C.mutagennogo and cancer is not Vemeno.wvedenie gidroxizina pregnant animals rodents (mice, rats, rabbits) in doses exceeding therapeutic dose for humans produced embryonic defects in Ploda.pri ingestion rapidly absorbed from the intestine, C_max achieved in 2 hours Passes through GEB and placenta (in fetalnah tissues focused to a greater extent than in the parent). Metabolised in the liver, the main metabolite - cetirizin. T_1/2 depends on the age of the patient and is 160161 (for children 2-10 years), 20 hours (for adults), 29 hours (for the elderly and very old); In patients with liver disease is increased to 37 hours Report mostly kidneys (0.8% in an unmodified form).

Indications

Severe anxiety, psychomotor stimulation of tension, irritability, and neurological and mental (generalized anxiety and the adaptation), and somatic diseases; Alcohol withdrawal syndrome; Premedikation and posleoperazionny period (in a combination therapy); Itching (symptomatic therapy).

Restrictions on the use of

Glaucoma, Denmark prostate gland, difficulty urinating, constipation, male, dementia, kidney and / or liver failure.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, incl. cetirizin to, or aminofillino etilendiaminu; porphyria, pregnancy, the birth of breast-feeding.

Side-Effects

From the nervous system and sensory organs : drowsiness, weakness (in the early days of admission), headache, Golovokrugenie.prochie : increased sweating, tachycardia, nausea, allergic reactions, dry mouth, the delay urination, constipation, the ccomodation eye.

Specific guidance

Injectable forms are only for the / m introduction.

Patient interaction

Do dampening effect on the central nervous system narcotic analgesics, barbiturates, tranquilizers, sleeping-, alcohol (to be selected individual dose). Prevents Development pressonego effect epinephrine, protivosudorojna fenitoina activity, action betagistina and blocking cholinesterase. Ters side effects (from the stomach) and theofillina бета_2-адреномиметико��).

Overdosing

Symptoms : gipersedation, tremor, convulsions, hallucinations, sputannosti consciousness, demotion AD, nausea, Rvota.lechenie : induction vomiting (in the absence of spontaneous), flush stomach, the general support measures, including monitoring of the vital functions of the organism. When arterial hypotension, a norepinephrine (but not epinephrine). Specific antidote exists. Haemodialysis ineffective.

Precautions

If such side effects as drowsiness and weakness do not disappear after a few days of treatment, it is necessary to reduce the dose. Avoid joint appointment with MAO inhibitors. To apply caution in patients prone to witness or receive protiwaritmicescie drugs, as well as from patients predisposed to sudorojnam Reackziam.v period of treatment should be avoided reception alcohol. When it is necessary to carry out tests allergologicakih reception gidroxizina should be discontinued 5 days before the study. Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, in / m. Adults : general practice, 25-100 mg / day in a number of techniques in psychiatry, and 300 mg / sut. The normal duration of the course of treatment is four weeks. In Anesthesiology : in / m adult-100-200 mg / day for Then-50-200 Mg.detam appointed depending on the age and mass Tela.pri same treatment means oppressive CNS, or holinoblokatorami need adjusting doses. Dose should be reduced in older patients (treatment start with half therapeutic dose), and kidney and liver failure.

Literature

1. Hantouche E., M. Ferrery The gidroxizina with generalized anxiety / / Psychiatry and psihofarmakoterapia .- 2000 .- T. 2-N 4.2. Loaders M., Scotto J.-C. Mnogocentrowoe comparative study gidroxizina, buspiron placebo double-blind method in patients with generalizovannami alarming conditions (extended abstract) / / Psychiatry and psihofarmakoterapia .- 2002 .- V. 4-N 2.

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