Medazepam

Chemical name

7-Хлор-2,3-дигидро-1-мети л-5-фенил-1H-1,4-бензодиа��епин (as hydrochloride)

Gross

C16-H15-Cl-N2

Characteristics

Melkochristalliceski sulphur powder. Virtually nerastvorim water easily in alcohol.

Of drugs

Drugs, the anxiolytic, protivosudorozhnoe, miorelaksirutee (central), and soothing. Interacts with the receptor benzodiazepinovmi limbic system and the upstream activator formations barrel brain contributed to the channels for chlorine ions, which leads to greater performance influences GABA in Zns.pri ingestion drawn 50-75%. C_max in plasma is achieved in 1-2 hours Fully associated with plasma proteins. Metabolised in the liver by gidrauxilirovania, N-demetilirovania and oxidation. Forms active metabolites : oxazepam (7% dose), desmetilmedazepam, diazepam and desmetildiazepam, the latter is a long-T_1/2 and probably has a sedative effect. T_1/2 medzepama is 20-176 hours Metabolites have large T_1/2 so after receiving medzepama even within 3-14 days of the significant concentration in the blood plasma. Provided in the form of metabolites (mainly glukuronida) through the kidneys (80%), and intestine (15-37%). Answers anxiety, fear, psihoneuroticeski voltage dwigatelnoe concern suetlivosti excess. Restores critical evaluation of their disease. Protivosudorozhnoe central miorelaksirutee, sedative, and the Swiss was to a lesser extent than that of typical benzodiazapine tranquillizers. SLEEPING to combine some properties enable slightly violates work during the day (it is assigned to the "daily" trankvilizatoram). Recommended for therapy weakened patients, older patients and children (in the absence of expressed miorelaksiruth and sedative properties). Appointed for a short time, because in the long-term employment, particularly in high doses, may develop mental Drug Dependence (physical dependence is not often). The child of a strictly on the grounds (less ability to memorize). In patients with chronic COPD infection in the use of high doses may alveolar development gipoventilation.

Indications

The adult concern, the offensive and fears of disorders, neuroses, neurozopodobne condition (for instance, the functional disturbance circulatory system, migraines, menopause syndrome), the withdrawal syndrome in chronic alcoholism. Children over-anxiety, "school" neuroses, emotional lability.

Restrictions on the use of

Serious liver and kidneys, I trimester of pregnancy (should strictly adhere indication for use), breast-feeding (should abandon breastfeeding).

Contraindications

Гиперчувствительност ь (including from other benzodiazepines), male.

Side-Effects

The sense of fatigue, headache (first reaction to the reception by Cravings following a lower dose), drowsiness, weakness, the ccomodation, tachycardia, increased muscle fatigue, loss of libido, impotence, menstrual irregularities, allergic skin reactions, drug dependency; In older patients and children, the loss of orientation, the absence of braking aggressiveness.

Patient interaction

Do (mutually) psychological effects, doses, drugs, alcohol and drugs etanolsoderjath, of narcosis and analgesics.

Overdosing

Symptoms : a sense of fatigue, ataxy, tachycardia, hypotension, low muscle tone; In the most severe cases, coma, convulsions, oppression Dahania.lechenie : washing stomach reception activated carbon and sodium sulphate; Correction respiratory and circulatory, symptomatic therapy. Forward diurez and Hepatology little effective.

Precautions

Is not recommended in conjunction with the transport drivers, operators and persons profession which requires quick mental and motor reactions. During treatment should refrain from receiving alcohol. In order to prevent the withdrawal syndrome to abolish product gradually.

Dosing and Administration

Inside, the food, squeezed small amounts of liquid. At the beginning of treatment, and 5 mg 2-3 times a day, then dose gradually increased to 30-40 mg per day. The outpatient encouraged to 5 mg morning and afternoon and 10 mg evening. Older patients and adolescents appoint 10-20 mg; Children 2 mg / kg / sut. The maximum daily intake for adults 60 to 70 mg. When treating chronic alcoholism drug use in the average daily dose for 1-2 weeks.

Directory → Neurotropic funds → Medicines → Medazepam