Meprobamate

Chemical name

2-Метил-2-пропил-1,3-проп андиола dikarbamat

Gross

C9-H18-N2-O4

Characteristics

Anksiolitik nebenzodiazepinova structure. The white crystalline powder with a characteristic odour and bitter taste. It is soluble in water, easily soluble in alcohol and acetone.

Of drugs

Drugs, the anxiolytic, miorelaksirutee, sedative. It has a dampening effect on the various divisions of the central nervous system, including Diencephalon and limbicescuu system. Miorelaksirutee due to the braking institute in the field of neuronal inserted side horns spinal cord, cheeks and hypothalamus. There has expressed impact on the vegetative nervous system. Several temperature reduces Tela.effectiven with mental illnesses involving hadst, either, anxiety, sleep disturbances, as well as in psihoneuroticeskih conditions associated with severe somatic diseases. As a sedative used in the circulatory dystonia, the primary forms of hypertension, ulcers stomach and duodenal ulcers, skin irritation and Dr.horosho drawn from the blood. Treated biotransformation in the liver with the formation of active metabolites. T_1/2 of plasma 10 h. Passes through the placenta, enters the breast milk (concentration in breast milk is 2-4 times higher than the concentration in plasma mother). Excreted in the kidneys (8-19% in unmodified form).

Indications

Neuroses, anxiety disorders, insomnia, menopausal and pre syndromes.

Pregnancy and lactation

Contraindicated in pregnancy (especially in the first trimester because it increases the risk of birth defects in the appointment during this period). At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, incl. other derivative carbamata; alcoholism, drug dependency, including in the disease, epilepsy, male, liver and / or kidney failure, acute porphyria peremejatayasa, pregnancy (especially I trimester), breast-feeding, age up to six years.

Side-Effects

From the nervous system and sensory organs : weakness, drowsiness, dizziness, headache, insomnia, impaired memory and attention giporeflexia, nervousness or anxiety, impaired coordination of movements, lack of view euphoria paradoxical reaction (unusual action), a false sense of Blagopolucia.so the circulatory system and blood (blood, gemostaz) : palpitations, tachycardia, incredible, demotion AD lakopenia, Trombozitopenia.so part of the intestine : reducing slunootdelenia, nausea, vomiting, diarrhoea, diarrhoea �вления.Аллергические �ection : skin rashes, itching, urticaria and Dr.vozmozhno addiction, drug dependency, the syndrome.

Specific guidance

It should be borne in mind that anxiety or stress in the day-to-day stress, usually do not require treatment anxiolitikami.

Patient interaction

Potenziruet effects of alcohol, analgesics, doses, of narcosis, and sleeping gipotenziveh preparations miorelaksantov peripheral.

Overdosing

Symptoms of acute toxicity : expressed sputannosti consciousness; Heavy dizziness; Breathing or slow or breathing difficulty; Slow heartbeat; Slabostj.simptoma significant chronic toxicity : long dizziness; Smazannaya it; Pochatawanie.lechenie : washing stomach, symptomatic therapy. Diurez effective (under control, in order to avoid dehydration), including : osmoticeski diurez (with mannita), Hepatology and peritonealny dialysis.

Precautions

Patients older should designate smaller doses. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of Vnimania.otmenu therapies were gradually (to avoid the development of the syndrome). Reducing slunootdelenia can lead to increased risk of gum, candidiasis of the oral cavity, caries.

Dosing and Administration

Inside, the food grown on 400 mg 2-4 times a day; Maximum single dose for adults is 800 mg, if necessary daily intake can be increased to 3 in the city of insomnia, 200-600 mg for 30 minutes before sleep. Children on the 200 mg 2-3 times a day. The course of treatment is 1-2 months.

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