Phenazepam

Chemical name

7-Бром-5-(2-хлорфенил)-1,3- дигидро-2H-1,4-бензодиаз епин-2-он

Gross

C15-H10-Br-Cl-N2-O

Characteristics

White or white with kremovatam white crystalline powder. Virtually nerastvorim in water and air, not soluble in ethanol, it is difficult in chloroform.

Of drugs

Drugs, the anxiolytic, protivosudorozhnoe, miorelaksirutee (central), Caritas, sedative. Benzodiazepinove stimulates receptors increases the sensitivity to Gamk-retseptorov mediatoru increases braking influence GABA in the CNS. Reduces anxiety subcortical structures of the brain, slowing polisinapticalkie spinale though. Decreases emotional stress reduces anxiety, fear, anxiety. Precautions have been arising epileptogennah points in the crust, and talamuse limbicakih brain structures by strengthening presinapticski braking (increased activity center is not reduced). Well drawn from the blood. Time to S_max 1-2 hours Metabolised in the liver. T_1/2 - 6-10 hours Excreted kidneys. Reducing liver and kidneys slows klirens and leads to cumulation.

Indications

Outwardly, neurozopodobne, psihopaticalkie and psihopatopodobne state accompanied by anxiety, fear, increased hadst, tension and emotional labilnostew; Sleep disorders, obsessive-panic disorder, phobias, reactive psychosis; Autonomic lability, ипохондрически-синес��опатический syndrome; apnoea seizures different etiology, and visocnaya mioclonica epilepsy, a nervous status, muscle rigidity, texture, atetoz, giperkinez; premedikation (as a component of the introductory narcosis); in the treatment of the withdrawal and dependence syndrome, schizophrenia (febrilnaya form Hypersensitivity to antipsihoticski means); prevent states fear and emotional strain.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Its infants, severe liver damage (cirrhosis, a disease Hungary), and kidney; Poisoning etc. tranquilizers, neiroleptikami, drugs, drugs, alcohol; Pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : dizziness, headache, drowsiness, impaired memory, concentration, coordination of movements, paradoxical agitation ataxy, Midriaz.so part of the intestine : dry mouth, nausea, Diarea.allergicakie reactions : skin rash, Zud.prochie : dizuria, muscle weakness, dismenorea, reduced libido, addiction, drug dependency.

Patient interaction

Do (mutually) doses of tranquilizers, antidepressants, tranquilizers, anaesthesia, analgeziruth, protivosudorozhnykh of alcohol.

Overdosing

Symptoms : expressed oppression consciousness, cardiac and respiratory Deatelnosti.lechenie : control of vital body functions, the maintenance of the respiratory and cardiovascular activities symptomatic therapy. The specific antagonist flumazenil (in / 0.2 mg of 5% glucose solution or 0.9% solution of sodium chloride), a dose increase to 1 mg.

Precautions

As a reader, removed or reducing some side effects may fenazepama Sidnocarba.s use caution in the use of organic cerebral insufficiency. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. To apply caution in old age and the children (daily dose reduces 2-3 times). At the time of treatment should abandon admission alcohol.

Dosing and Administration

Inside, in the / m or / in (struino or drip). Non-dose 0.5-1 mg, the average daily intake - 1.5-5 mg (at 0.5-1 mg morning and afternoon and 2.5 mg per night), the maximum daily intake - 10 Mg.epilepticeski status serial epileptic seizures-initial dose of 0.5 mg dropped and then on October 2 мг/сут.Неврологическа я practice (of high muscular tone), the inside of 2-3 mg 1-2 times a day or / m 0.5 mg 1-2 times a Sutki.narushenia sleep-inside the 0,25-1 mg (if necessary, to 2.5 mg) for 20 to 30 minutes before the cravings Sna.alkogolnaya-on the inside of 2.5-5 mg / Sut.premedikation in / in slowly 3-4 mg (3-4 ml of 0.1% solution). The course of treatment with oral-2 weeks (if necessary, up to 2 months), with Injecting admission to 3-4 weeks.

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