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Relanium

See also Diazepam

Roman name

Relanium

Pharmacokinetics

After the / m of diazepam fully absorbed and uneven. Bioavailability of the drug in / m of less than after oral introduction. The drug is 30 to 60 minutes. C_max after the / m imposition achieved through 60 minutes from the time after Wvedenia.diazepam in / in a very rapidly distributed in the tissues, especially in the brain and liver. Protivosudorozhnoe effect occurs in a few minutes after the introduction. C_max diazepam plasma variable and depends on the dose. C_max plasma is 15 minutes. Associated with the protein to 95-99%. Passes through the placenta and Geb.objem distribution varies and depends on the age, body mass index, sex patient is 0,18-1,7 l / Cg.metaboliziruetsa in the liver to active metabolites : N-demetildiazepama, temazepama and oxazepamum. N-demetildiazepam (nordiazepam), and diazepam which is metabolized in 50%, 26.3 in the brain and has T_1/2 50 hrs (nordiazepam); More responsible for a long and strong protivosudorozhnoe action of the preparation. Connections to be metabolizmu by demetilirovania gidrauxilirovania and are linked to acid glukuronova approximately 50% (range 20,7-68,2%), and approximately 15% jelchew (1,99-26,76%). There was pechenern-kishecnaya circulation diazepam and N-demetildiazepama. T_1/2 diazepam imposed / in the way is 32 hours Full kidney Cl is 20-33 ml / Min.u elderly T_1/2 increasing. In patients with liver failure T_1/2 increasing and decreasing kidney Cl. People with kidney failure, in the absence of sufficient data farmakokineticeskih recommended dose reduction Vdvoe.diazepam and his first active metabolite pass through placental barrier by passive diffusion, enters the breast milk.

Indications

The fear and anxiety, alcohol deliri, premedikation, convulsions, muscle gipertonus, tetanus, eclampsia (children, pregnant).

Pregnancy and lactation

Contraindicated in pregnancy (I term). At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, narrow-angle glaucoma, infants, respiratory failure (severe chronic or gipercapniei) night syndrome patients, heavy alcohol deliri expressed by the human liver and kidneys, ataxy, pregnancy (I term), breast-feeding, age up to 2 years.

Specific guidance

Using drugs should refrain from work requiring quick reaction Sentences (driving transport, the mechanisms).

Patient interaction

Potenziruet psychological effects, doses, alcohol.

Precautions

Be wary appoint patients older patients with human liver and kidney diseases organic substances, heavy heart failure and respiratory failure (to be reduced by half dose).

Storage conditions

In the dark place at a temperature of 15-25 ° C

Shelf life

5 years

The registration

015758/01

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