Tofisopam

Chemical name

1-(3,4-Диметоксифенил)-5-��тил-7,8-диметокси-4-мет��л-5Н-2,3-бензодиазепин

Gross

C22-H26-N2-O4

Characteristics

The white with a yellowish sheen crystalline powder. Virtually nerastvorim water, it is difficult soluble in alcohol.

Of drugs

Drugs, the anxiolytic, psihostimulirutee. Do Gamkmimeticalkie processes in the central nervous system. And wegetocorrigiruta and stressprotectivna activity is not accompanied by a pronounced sedative, and miorelaksirutm protivosudorojnam action. Increase coronary Sosuda.bystro and completely absorbed in the digestive tract, is C_max two hour T_1/2 is 6-8 h resulting biotransformation products anksioliticski influence is not. Return with urine (60-80%) in the form of glukuronidov, the remaining 20% excreted in faeces. Not koumouliruet.

Indications

Neuroses, Psychopathy, патохарактерологичес кое personal development; state, accompanied by emotional stress, wegetativei disorders, fear, apathy, decreased activity unacceptable feelings; Reactive depression with moderately expressed psihopatologicakimi symptoms, a lack of initiative, weakness, cardialgia (alone or in combination with other drugs), stenocardia, deliriosnye condition (for the lifting of the institution and vegetative symptoms), alcohol cravings, menopausal syndrome; male, myo, neurogenic muscle atrophy and other pathological states with secondary neurotic symptoms, in which protivopokazana anxiolitiki with the expressed miorelaksirutm action.

Contraindications

Hypersensitivity, psychoses and the Psychopathy expressed motor excitation, aggressiveness or deep depression, asthma respiratory distress, exantema, pregnancy, especially in the I and III trimenon, breastfeeding (for the period of treatment ceased), engaging in vigorous activities that require concentration, quick reaction (when it is not possible to exempt from work).

Side-Effects

206 arousal, irritability, aggressiveness, anxiety, sleep disturbances, nausea, gastralgii, skin itch, exantema.

Patient interaction

Deprimirote to reinforce (each) oppression CNS. Metoclopramide up offensive effect (increased speed removals as a result of the increase peristalsis of the bowel).

Overdosing

Symptoms : deep sleep, development Koma.lechenie : restoration respiratory and cardiovascular activities.

Precautions

In affeguo-shokovh conditions and severe depression monotherapy is not recommended because can mask symptoms and inhibiting diagnosis (using aggressive combination therapy with antidepressants). Finished treatment the steep drop in single and daily doses (prevention syndrome "lifting"). Permanent medical follow-up is required in the appointment of patients with myasthenia.

Dosing and Administration

Inside 50-100 mg / day (maximum dose of 300 mg) in the reception 1-3 in the 12 weeks, including the phasing out of the preparation. The children, the elderly and the sick somatic dose reduced twice.

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