Амитриптилин-гриндек��

Roman name

Amitriptyline-Grindex

The composition and the form of

1 tablet contains amitriptilina (as hydrochloride) 10, or 25 mg; blistere in 10 pcs. , in a cardboard bundle 5 blisters.

Of drugs

Antidepressive, anxiolytic, sedative, antidizuricescoe. The antidepressive action amitriptilina linked to the oppression of reverse takeover neironalnogo catecholamines (norarenalina, dopamine, serotonin) in the central nervous system. Amitriptyline is an antagonist muskarinovykh holinergicakih receptors in the central nervous system and in the periphery. It has antihistamines (H_1) and antiadrainergicakimi properties.

Pharmacokinetics

The ingestion of material is 33-67% C_max in plasma achieved through 4-8 hours When the / m C_max a plasma above and achieved before. Metabolised in the liver with the formation of the active metabolita nortriptilina. Return, for the most part, with the urine. T_1/2 amitriptilina for 10-28 h in nortriptilina 16-80 hours Full withdrawal has been going on for seven days. Amitriptyline passes through the placental barrier, enters the breast milk in concentrations similar to plasma.

Indications

Depression (especially effective when тревожно-депрессивны�� Conditions), mixed emotional disorders and conduct disorders fobicakie, child enourez (with the exception of children with gipotoniceski bladder), psychogenic anorexia, boulimiceski anxiety, severe pain neurogennogo nature.

Pregnancy and lactation

Contraindicated. At the time of treatment breastfeeding deleted.

Contraindications

Hypersensitivity, oppression toxic substances, decompensirovanny heart disease, acute and recovery myocardial infarctions and conductivity of the cardiac muscles, hypertension III degree, acute liver disease and kidney disease blood disease hospital of stomach and duodenal ulcer in the process of being increased, glaucoma, Denmark prostate, atony bladder pilorostenoz, paralysis occlusion bowel up to 6 years, pregnancy, breast-feeding, the application of the MAO inhibitors.

Side-Effects

From the circulatory system and blood (blood, gemostaz) : tachycardia, incredible, ortostatical arterial hypertension, agranulozitos and other changes Krovi.so part of the intestine : disease, the taste, anorexia, nausea, vomiting, feeling discomfort epigastrii violation of the liver (rarely). From the metabolic : ginekomastia, galactorea change secreta exists, reduced libido, potency, increased body mass index in the long Primenenia.prochie : skin rashes, hair loss, increased lymph nodes.

Specific guidance

Adjournment of treatment between receiving MAO inhibitors and amitriptilina (and other tricyclic antidepressants) should not be less than 14 days.

Patient interaction

Using the neiroleptikami and sedatives and hypnotics means protivosudorojnami drugs, and the central control analgetikami, with the means of narcosis, alcohol is potentiation oppressive actions in the central nervous system. Amitriptyline potenziruet gipertenzivny effect of catecholamine, but ingibiruet of drugs affecting norarenalina release. Amitriptyline blocks antihypertensive activity guanetidina and drugs with similar mechanism of action. Together with the admission zimetidine concentrations amitriptilina plasma. Simultaneous reception MAO inhibitors can be fatal.

Overdosing

Symptoms : drowsiness, disorientation, sputannosti consciousness, the pupils, increased body temperature, dizziness, dizartria, causing hallucinations, apnoea seizures, muscle rigidity, stalemate, coma, vomiting, irregular Arterial gipotenzia, heart failure, oppression Dahania.lechenie : cessation therapy amitriptilinom washed stomach cefuroxim fluid in / m or / with a fizostigmina 1-3 mg every 0.5-2 h (children introduction fizostigmina start with doses of 0.5 mg, and then repeat dose with a minute intervals to determine the minimum effective dose, but not more than 2 mg). Physostigmine should be used only in patients with coma, oppression breathing epileptic severe arterial gipotenziei expressed aritmiei heart; Symptomatic therapy, maintenance and AD vodno-elektrolitnogo balance. Showing monitor cardiovascular activity (ECG) for a period of five days, as relapse can happen in 48 hours and later.

Precautions

At the time of treatment amitriptilinom prohibited driving vehicles, servicing arrangements and other jobs requiring greater attention.

Dosing and Administration

Inside, during or after delivery. Initial daily intake - 50-75 mg divided by the reception 2-3, as appropriate dose gradually (25-50 mg) to make best-150-200 mg / day (most of the daily intake are at night). In severe depression resistant to therapy : 300 mg or more, the maximum dose portable. After enduring antidepressive effect 2-4 weeks dose gradually Umenyshaut.pri light violations in outpatient facilities : the sick elderly, 25-50 mg, a maximum of 100 mg in divided doses or by the Snom.enourez : children over six years 12,5-25 mg at night (but not more than 2.5 mg / kg). To prevent migraines, for chronic pain neurogennogo nature (including long-term headaches) : from 12,5-25 mg to 100 mg / sut.

Directory → Neurotropic funds → 24.2.1 → Амитриптилин-гриндек��