Амитриптилин-словако��арма

Roman name

Amitritlin Slovakofarma #

The composition and the form of

1 jar amitriptilina contains 25 mg; in vial 50 pc. , in a carton one bottle.

Of drugs

Antidepressive, sedative, antigistaminnoe. Ingibiruet return neironalny hostage mediator monoaminov, including noradrenalin, dofamin, serotonin, etc., which leads to an accumulation of mediators in the field of receptors and enhance adrenergicski and serotoninergicski action. M-holinoretseptora block.

Pharmacokinetics

Well drawn. Metabolized in the liver is the major metabolite nortriptilin. Provided with urine (mainly in the form of metabolites), T_1/2 - 9-25 h, the nortriptilina, more. Passes as nortriptilin through the placental barrier, enters the breast milk.

Indications

Stress syndrome with psychosis, depression (endogenous, inwaluie, rocket-propelled, neurotic, and organic brain damage, medication), a depression in childhood (boyazlivosti, timidity, anxiety, fear society), emotional distress, violation of the conduct enourez, faecal incontinence psychogenic anorexia.

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy, breast-feeding.

Contraindications

Glaucoma, epilepsy, paralysis occlusion bowel pilorostenoz.

Side-Effects

Drowsiness, weakness, disorientation, hallucinations, psychosis, deliri, ekstrapiramidnye disorders, drugs, the dryness and kislo-gorki taste in the mouth, constipation (up to paralysis bowel obstruction), jaundice, urine retention, skin, visual impairment, ccomodation disorders, tachycardia, hypotension ortostatical, heart disorders conductivity, arrythmia, the blood, lowering potency, changing face, ginekomastia, galactorea, allergic reactions.

Patient interaction

Do effect antiparkinsonicakih funds (holinoliticski) fenotiazinov, vazodilatatorov, tiazidnykh dioretikov, narcotic analgesics, alcohol, psihostimulatorov weakens - protivosudorozhnykh and hypotension caused rezerpinom, guanetidine. Increases the simpatomimetikov.

Overdosing

Perhaps only after 3-5 days, the increasing incidence described side effects.

Precautions

With caution in disease, tachycardia, arrhythmia, heart failure, thyroid prostate cancer (relative contraindications). Nor should appoint more 6-8 months.

Dosing and Administration

The inside is not liquid, squeezed enough liquid at certain times of the day (usually evening) for the 50 mg, with a gradual increase in dose within 5-14 days to 150 mg per day. The disappearance of signs of depression reduces the dose to 50 mg and continuing to be treated at least three months. In old age and light violations is 50-100 mg / day (1 x overnight). When night enuresis in children - 12,5-25 mg per night. Children of school age on 12,5-25 mg 1-3 times a day.

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