Citalopram

Chemical name

1-[3-(Диметиламино)проп��л]-1-(п-фторфенил)-5-фта��анкарбонитрил

Gross

C20-H21-F-N2-O

Of drugs

Drugs, the antidepressant, sedative. Yes ingibiruet return neironalny taking serotonin in the brain, blocking gistaminove, m-holino- and adrenoretseptora and zitohrom P450. Normalizes the emotional sphere, improves pathologically changed mood withdraws yearning, melancholy. Does motor activity and accelerates processes in thinking Depresciah.pri ingestion C_mah is 2-4 hours Bioavailability of 80%, tying with blood plasma is less than 80%. After 1-2 weeks of therapy in the plasma equilibrium concentration. Biotransformiroetsa in the liver with zitohroma P450 (demethylation, dezaminirovanie, oxidation), and significantly hampered the activity. T_1/2 is 1.5 days. Report kidneys and digestive tract. Antidepressant effect is 2-4 weeks of treatment.

Indications

Depression different etiology and structure (in adults).

Contraindications

Hypersensitivity, pregnancy, breast-feeding (for the period of treatment stop breastfeeding).

Side-Effects

Drowsiness, dry mouth, nausea, increased sweating, tremor, seizures apnoea, aetiology (with initially low HR).

Patient interaction

Do effects of sumatriptan, etc. serotoninergicakih products; Zimetidin improves the equilibrium concentration in the blood. Together with the admission of MAO inhibitors can hypertonic kriz (serotoninovy syndrome).

Overdosing

Symptoms : drowsiness, of rhetoric, coma; Occasionally, big apnoea seizures, increased sweating, sinusova tachycardia, zianoz, giperventilatia light, nausea, Rvota.lechenie : washing stomach, maintaining vital functions.

Precautions

Be wary appoint persons working with potentially dangerous machinery or by vehicles (reduced ability to focus and increasing the reaction time). Not recommended combined with MAO inhibitors or designate in the first two weeks after the sanctions have been lifted. In developing the obsessive should stop reception.

Dosing and Administration

Inside, on one occasion, at any time of the day, regardless of the meal. Initial dose of 20 mg per day, maximum 60 mg / sut. Old-daily doses of 20 mg, the maximum is 40 mg / sut. When liver failure that the use of minimal doses.

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