Clomipramine

Chemical name

3-Хлор-10,11-дигидро-N,N-ди метил-5Н-дибенз[b,f]азеп ин-5-пропанамин (and as hydrochloride)

Gross

C19-H23-Cl-N2

Of drugs

Drugs, the antidepressant, sedative, psihostimulirutee. Does катехоламинергическу ю transfer to the central nervous system (through oppression reverse takeover neironalnogo mediators and has a larger impact on the taking of serotonin). And adrenoblokiruta (mostly alfa_1), and m-holinoliticaskoy antigistaminna activity. Psihostimulirutee effect was less than in imipramina and sedate weaker than amitriptilina. The effect occurs in the first week of treatment.

Indications

Stress syndrome (monetary, reactive, neuroticeski organic, larvirovanny, inwaluzionny) psihopatia, schizophrenia, chronic pain and somatic diseases, distimicescie of the psihopaticakih disorders among children and adolescents, the obsessions and phobias, catalepsy narcolepsy, nighttime urinary.

Contraindications

Гиперчувствительност ь (including from other antidepressants in the group dibenzazepina) recently moved myocardial infarction, treatment MAO inhibitors, pregnancy, breast-feeding (should abandon breastfeeding).

Side-Effects

Brown mouth, sweating, tremor, dizziness, paresis ccomodation whose influence, ortostatical hypotension, block, allergic skin reactions. Seldom-of the liver, giperpireccia, convulsions, agranulozitos.

Specific guidance

During treatment should avoid alcohol.

Patient interaction

Incompatible with MAO inhibitors.

Overdosing

Many violations conductivity and aritmiei, insomnia, sputannostew consciousness, or the rise of xenophobia. Showing scene stomach; With heavy antiholinergicakih symptoms - 0.5-2 mg fizostigmina in / in or / m.

Dosing and Administration

Inside, and depression and fobiah appoint 25 mg 2-3 times a day; In the first week dose gradually increased to 50 mg three times a day, and then (after a clinical effect) are in the process of supporting 25 mg 2-3 times a Sutki.v / m imposed on 25-50 mg / day, dose gradually increased to 25 mg daily to 150 mg / sut. B / drip to impose on 50-75 mg (rastvoriv in izotonicescom solution of glucose or sodium chloride) in the feature one hour every day. When chronic pain dose of 10-150 mg / day; Older initial daily dose of 10 mg, with a gradual increase to 30 to 50 mg / day for 10 days. For children initial daily dose of 10 mg, with a gradual increase in the 10 days to 20 mg / day (aged 5-7 years) to 50 mg / day (ages 8-14 years), and 50 mg / day (over the age of 14 years).

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