Directory → Neurotropic funds → 24.2.1 → Deprenon
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DeprenonSee also FluoxetineRoman nameDeprenonThe composition and the form of1 capsule contains fluoksetina hydrochloride 22.4 mg (equivalent to 20 mg fluoksetina); blistere in 10 pcs. , in box 2 blisters.Of drugsAntidepressive.PharmacokineticsThe ingestion rapidly and completely absorbed, bioavailability 60%. C_max achieved through 6-8 hours In the blood of 90% is associated with malnutrition. Accumulating in the tissues, permeates through GEB and breast milk (up to 25%). The liver demetiliruetsa to norfluoksetina (active), and turned into a series of unidentified metabolites. Report the news, Cl is 94-704 ml / min (norfluoksetina, 60-336 ml / min). About 12% of output decreases. T_1/2 fluoksetina 2-3 day, norfluoksetina, 7-9 day.FarmakodinamikaSelectively blocking reverse neironalny taking serotonin (5-NT) neurotransmission in the central nervous system, increases its concentration in synaptic junctions increases and prolong effect on postsinapticalkie receptors. Improves mood eliminates disforiu, reduces appetite. Reducyruet обсессивно-компульси��ные disorder. Does taking serotonin trombozitami rights.IndicationsDepression, anxiety boulimiceski, обсессивно-компульси��ные disorder.Pregnancy and lactationContraindicated. At the time of treatment should stop breastfeeding.ContraindicationsHypersensitivity, atony bladder, severe violations of the kidneys and liver, glaucoma, prostate adenoma cancer, asthma epilepsy, sudorozhny syndrome of different genesis, child.Side-EffectsFrom CNS : obsession; Increased suicidal tendencies, alarm; Headache, tremor, dizziness, sleep disturbance, reducing Libido.so the intestine : reduced appetite, nausea, vomiting, Diarea.so the urogenital system : incontinence, or urine retention, dismenorea, Waginit.prochie : itching, fever, the fever, pain in muscles and joints, gipotenzia, tachycardia, violations Conclusion giponatriemia, allergic reactions.Patient interactionRisk Development serotoninergicski syndrome increase MAO inhibitors, antidepressants, furazolidon, procarbazine, selegilin, triptofan. Following the lifting of MAO inhibitors appointment be no earlier than 14 days after the fluoksetina only five weeks. Do effects of alcohol, drugs, the oppressive Corporation, gipoglikemicakih and anticoagulants. Does metabolism and tricyclic antidepressants isoquinolines. Increases concentration of lithium in blood.OverdosingSymptoms : ajitation, dwigatelnoe concern habits, apnoea seizures, violation of a heart rhythm (including tachycardia), nausea, Rvota.lechenie : washing stomach, the appointment of activated carbon symptomatic therapy : maintaining heart and respiration (in fits - diazepam).PrecautionsBe wary of during the drivers of vehicles and people skills relate to the high concentration of attention.Dosing and AdministrationInside. Initial dose of 20 mg in the morning; And then (if necessary) 40-60 mg / day in 3 Priema.pri boulimicescom neuroze : 60 mg / day in the reception 2-3 (in the old age-20 mg / day). The maximum daily dose of 80 mg.Storage conditionscaps. : List B. The temperature is not above 25 ° CShelf lifecaps. : 4 g. |
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