Directory → Neurotropic funds → 24.2.1 → Doxepin
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DoxepinSee also DoxepinRoman nameDoxepinThe composition and the form of1 capsule contains doksepina 10, or 25 mg; blistere in 15 pcs. , in box 2 blisters.Of drugsAntidepressive, anxiolytic, sedative. Ingibiruet return neironalny hostage biogenic amines (norarenalina, serotonin), the central blocks H_1-retseptora has holinoliticaskoy and альфа_1-адренолитичес��ой activity.PharmacokineticsQuickly and completely absorbed in the digestive tract. C_max through 1-3 hour equilibrium concentration (30-150 µ g / ml), in 2 Weeks Penetrates the GEB and placental barrier milk in nursing mothers. Demetiliruetsa in the liver to demetildoksepina. T_1/2 24-hour demetildoksepina - 33-80 hours Return with urine in the form of metabolites.Clinical pharmacologyIs moderate antidepressant effects (pronounced influence on the mood, in 10 to 14 days from the start of the reception).IndicationsDepressive state accompanied by Anxiety (in particular, presentarceskih, old inwaluih, rocket and postnatal psihozah in маниакально-депресси��ном psychosis), disorders, sleep disturbance Neurotic genesis, lungs delirium syndromes encountered in the treatment of chronic alcoholism.Pregnancy and lactationContraindicated.ContraindicationsHypersensitivity, glaucoma, prostate adenoma cancer, acute myocardial infarction, the plight of the kidneys, liver and blood system, a children's age (up to 12 years).Side-EffectsHeadache, dizziness, drowsiness or insomnia, sputannosti consciousness, disorientation, anxiety, excessive sedation, nausea, vomiting, constipation, dry mucous membranes cavity and the nose, tachycardia, or aetiology, muscle tremor, increased sweating, skin rashes, itching of the skin.Patient interactionDo effects of atropine, levodopa increases toxicity barbiturates, morphine and pethidine. Combining with neiroleptikami requires dose reduction of 50%, with lithium can cause severe pernitsiosny neuroticeski syndrome. Ethanol increases sedativuyu activity.PrecautionsNot used with MAO inhibitors (should be abolished in 2-3 weeks), sulfopridom, hlorpromazinom, hinidine, with caution, with glycosides naperstanki and baklofenom. During the treatment can not be controlled vehicles or work with the moving mechanisms. To apply caution in the elderly, debilitated, with severe cardiovascular diseases.Dosing and AdministrationInside. Initial dose-10-25 mg a day three times a day; Moderate and heavy neurotic states, and 150 mg / day (maximum daily dose is 300 mg); Children over 12 years of age is 0.5 mg / kg per day.Storage conditionscaps. : List B. In dry place at room temperatureShelf lifecaps. : 4 g. |
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