Fluoxetine

Chemical name

{+}-N-Метил-гамма-[4-(триф торметил)фенокси]бенз олпропанамин (and as hydrochloride); razemical (50/50) mixture of R-and S-enantiomerov

Gross

C17-H18-F3-N-O

Characteristics

White or no white crystalline powder with vodorastvorimostew 4 mg / J

Of drugs

Drugs, the antidepressant. Effective with endogenous depression and обсессивно-компульси��ных disorders. Improves mood, reduces tension, anxiety and fear, eliminates disforiu. Ingibiruet reverse takeover in serotonin neurotransmission, muskarinove blocks, and gistaminove альфа_1-адренергическ��е CNS receptors. Persistent clinical effect occurs in 1-2 weeks Lechenia.posle single injection 40 mg inside C_max plasma is the 6-8 h of 15-55 ng / J Capsule and aqueous solution preparation bioekvivalentna, eating does not affect the bioavailability. In concentrations up to 1000 ng / ml fluoxetin to 94.5% associated with the blood supply, including albumin and alfa_1-glikoprotein. Both forms enantiomernykh ekwieffective but S-fluoksetin appears slower and prevails over R-forma the equilibrium concentration. The liver enantiomers demetiliruyutza norfluoksetina before. T_1/2 fluoksetina 1-3 days of a single application and 4-6 days after reaching equilibrium concentration. T_1/2 norfluoksetina - 4-16 days, in both cases, which is a significant accumulation of active forms, a slow their equilibrium level in the plasma and long-term presence in the body after cancellation. In patients with liver cirrhosis T_1/2 extended by 3-4 times.

Indications

Depression, обсессивно-компульси��ные condition, bulimia, anorexia, alcoholism.

Contraindications

Hypersensitivity, the MAO inhibitors (in the previous two weeks), liver and kidney failure, epilepsy, apnoea state history, suizidalnaya spirit, diabetes, pregnancy and breastfeeding (for the period of treatment to termination).

Side-Effects

Anxiety, nervousness, weakness, sleep disturbances, rapid fatigability, headache, dizziness, tremor, the apnoea, reduced libido, anorexia, loss of body weight, nausea, vomiting, neuralgia, dry mouth, diarrhea, increased saliva, skin rashes, urticaria, which is often associated with systemic violations of the lungs, kidneys or liver, vasculita.

Patient interaction

Incompatible with MAO inhibitors, triptofanom. Changes lithium concentration in the blood.

Overdosing

Symptoms : nausea, vomiting, bringing CNS, gipomania, Sudorogi.lechenie : induction vomiting or stomach wash, the appointment of activated carbon, symptomatic and supportive therapy.

Precautions

In Hepatic and old age treatment should start with polovinnah doses with caution to appoint cardiovascular diseases, severe liver insufficiency and kidney school activities that require increased attention and high speed response (driving vehicles, the operators). The period between the cancellation of MAO inhibitors and the reception fluoksetina must be more than 2 weeks, and the abolition fluoksetina and receiving MAO inhibitors at least five weeks.

Dosing and Administration

Inside. The depression-20 mg in the morning increasing to a maximum of 80 mg 2-3 admission; With bulimia, 60 mg 3 admission; The обсессивно-компульси��ных states, 20-60 mg / sut.

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