Fluvoxamine

Chemical name

(E)-5-Метокси-1-[4-(трифто��метил)фенил]-1-пентано н-0-(2-аминоэтил)оксим (and as maleate)

Gross

C15-H21-F3-N2-O2

Characteristics

White or colourless crystalline powder. It is soluble in alcohol and chloroform, poorly soluble in water, virtually nerastvorim broadcast.

Of drugs

Drugs, the antidepressant. Selectively ingibiruet return neironalny taking serotonin from the synaptic junctions presinapticescoy space and increases its concentration in the central nervous system. The reduced number and sensitivity mediatoru serotonin receptors. At adrenergicakie, muskarinove and gistaminove brain structures not Vlijaet.posle intake of a well-absorbed. Bioavailability is about 53%. C_max achieved through 4-8 hours The plasma protein binds 80%. Treated biotransformation in the liver with the formation of the active-metabolita norfluoksetina and 5 inactive metabolites. 94% excreted in the urine within 71 hours The effect is a 1-4 week.

Indications

Depression.

Restrictions on the use of

Breast-feeding (at the time of treatment should be discontinued).

Contraindications

Hypersensitivity, violations of the liver and kidney failure, diabetes mellitus, epileptiformnye seizures in history, pregnancy, child.

Side-Effects

Headache, insomnia, irritability, and gipomaniakale maniakale condition, tachycardia, sinusita, pharyngitis, bronchitis, coughing, diarrhoea disorders, xerostomia, arthralgia, mialgia, allergic reactions.

Patient interaction

Do side effects of alcohol, means oppressive central nervous system, anti, cardiac glycosides, lithium salts, MAO inhibitors, triptofana.

Dosing and Administration

Inside. Initial dose for adults is 100 mg once. With good endurance dose increase to 150 mg per day in 2-3 reception. The maximum daily dose is 300 mg.

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