Frameks

Roman name

Framex

Pharmacokinetics

Once inside well absorbed from the digestive tract. Associated with the plasma protein up to 95%. C_max achieved through 6-8 hours Metabolised in the liver, with the participation of izofermenta P450 2D6 system zitohroma R450, the main active metabolite - norfluoksetin. T_1/2 fluoksetina 4-6 days norfluoksetina - 4-16 days. Report the news in the form of metabolites.

Indications

Depression, обсессивно-компульси��ные disorder.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, the MAO inhibitors (in the previous two weeks), pregnancy, breast-feeding, child.

Patient interaction

Incompatible with MAO inhibitors; Adds in plasma tricyclic antidepressants and fenitoina changes lithium concentration in the blood increases T_1/2 diazepam.

Dosing and Administration

Inside, the initial dose of 20 mg / day morning, in the absence or lack of effectiveness in a few weeks the daily dose can be increased with a maximum daily dose of 80 mg in 2 admission (morning and afternoon). Patients with human liver or kidney reduce the dose or increase the interval between meals.

Storage conditions

List B. In the dark place at a temperature of 15-25 ° C

Shelf life

3 years

The registration

011676/01-2000

The drug forms

The contents of the capsules : white powder or almost white Tsveta.kapsula : samozakravatayasa, jelatinova firm, the size of N3, the top and bottom of the blue.

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