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Lerivon

See also Mianserin

Roman name

Lerivon

The composition and the form of

1 tablet coated liner contains mianserina hydrochloride 30 mg, as well as support material (potato starch, silicon dioxide kolloidnyi, magnesium stearate, methylcellulose, calcium gidrofosfat, metilgidroksipropilzelluloza, polyethylene, titanium oxide); in a contour acheikova packing 10 pcs. , in a cardboard bundle two packaging.

Characteristics

Male Film-coated, white oblong have dvoyakovpukluu form code on the front side and labeled "Organon" on the other, with transverse mark on the face поверхности.Относитс�� group �иперазино-азепиновых �roizvodnykh and differs from tricyclic antidepressants (TTA), the lack of side chain characteristic of TTA.

Pharmacokinetics

If ingestion is rapidly absorbed from the digestive tract, bioavailability is 20%. C_max blood achieved through 3h Linking blood supply-about 95%. Equilibrium concentration in the blood is achieved after 10 days of admission. Metabolised in the liver by demethylation and oxidation followed kongugaciei metabolites. Return with urine and faeces. T_1/2 - 21-61 hrs (that allows for a drug once a day).

Clinical pharmacology

When used in therapeutic doses is not holinoliticaskoy activity is not having a significant impact on the cardiovascular Sistemu.effectiven with depression combined with anxiety, as well as in the case of sleep disorders in the face of depression.

Indications

Depressive of different genesis.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, maniakalny syndrome, severe violations of the liver, acute period myocardial infarction, pregnancy, breast-feeding, age and 18 years of age.

Patient interaction

Do dampening effect of alcohol on the central nervous system. Incompatible with MAO inhibitors. Lerivon not to affect the operation of such property as betanidin, clonidine, methyldopa, or guanetidin propranolol, incl. , in conjunction with gidralazinom.

Precautions

It should not be used in conjunction with MAO inhibitors, and for the next two weeks after the end of the course of treatment of the funds. The dual therapy hypotensive drugs should be monitored Ad.patientam being treated, especially in the first time, to refrain from driving, traffic management systems and other activities requiring high speed and reactions, as well as the use of Alkoghola.pri gipomaniakalnah states convulsions reactions jaundice treatment should be discontinued. Perhaps a granoulozitopenia agranulozitoza and four to six weeks of treatment (function bone marrow completely restored after the end of the course). Compulsory blood in the event of fever, pharyngitis, stomatitis or other signs of infectious diseases. Patients with uzkougolna glaucoma and suspected suffering prostate cancer should be under medical supervision.

Dosing and Administration

Inside (With the pills with liquid, squeezed water or other liquid), preferably in a time overnight, but can be divided daily dose for a few receptions. Dose and duration of treatment picked individually. Adults recommended initial dose of 30 mg / day with a possible increase to achieve an optimal therapeutic effect, the average effective dose, 90 mg / day; Older patients, beginning with the 30 mg / day, followed by a gradual increase in dose (supporting effective dose may be slightly lower than for patients adulthood). The inefficiency of the 2-4 weeks of therapy daily dose can be enhanced, in the absence of a positive effect in the next 2-4 weeks treatment Lerivonom cease. After the clinical improvement should continue treatment for 4-6 months.

Storage conditions

List B. In a dry, the dark place at a temperature of 900 ° C

Shelf life

5 years

The registration

013340/01-2001

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