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Melipramin

See also Imipramine

Roman name

Melipramin

Pharmacokinetics

Well absorbed from the intestine into the reception. C_max plasma in the / m is a 30 to 60 min. T_1/2 ranges from 4 to 28 hours Treated metabolizmu intense in the liver with the formation of the active metabolita desipramina. Both substances are associated with plasma proteins (imipramin - 60-96%, desipramin - 73-92%). Easily permeates through GEB and placental barriers into the breast milk. Write mainly kidneys.

Farmakodinamika

Antidepressive effect develops gradually. Optimal therapeutic effect is achieved through 1-3 (possibly) four weeks after the start of treatment.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, liver and / or kidney failure, heart failure, acute myocardial infarction, incredible, a combination of the MAO inhibitors, zakratougolnaya glaucoma, prostate adenoma cancer, atony bladder, diabetes under decompensation (injection), pregnancy, breast-feeding, child age (injection), to the age of 6 years (tablets).

Patient interaction

Incompatible with MAO inhibitors. Atropine and antiholinergicakie substances increased side effects because m-holinoblokirutego action. Funds depressing central nervous system, and alcohol increase sedative effect. Benzodiazepines and Low neiroleptiki increase sedative and antiholinergiceski effect. Anti tireoidnykh hormones increase antidepressant effect imipramina. Imipramine reduces antigipertenzivny effect simpatolitikov (eg octadina) and альфа_2-адреномиметик��в (clonidine, metildofa). Do pressornoe the adrenomimetikov (primarily adrenaline and norarenalina) weakens protivosudorozhny difenina effect. Inductive enzymes (alcohol, nicotine meprobamat, barbiturates, противоэпилептически е means) up imipramina metabolism and reduce the concentration of substances in blood plasma and its antidepressant effect. Zimetidin, methylphenidate, oral contraceptives, steroids, neiroleptiki, selective inhibitors of reverse takeover neironalnogo serotonin metabolism slowed imipramina, thereby increasing the antidepressant effect and toxicity of the drug. Tricyclic antidepressants increase doses concentration in plasma.

Precautions

Be wary appoint patients with ADHD or ajitaciei epilepsy (in the early days of treatment possible epileptic fit), gipertireozom, congestive heart failure, feohromotsytoma and acute porphyria (because of the threat of disease increased with the development of kriza) overdetermination prostate gland and / or unwilling to persistent zaporam, heart, liver and / or kidney failure, diabetes mellitus patients older. Maintenance treatment in a period of not less than three months. Lifting products are gradually, in order to avoid symptoms of "lifting" (nausea, headache, irritability, insomnia, irregular, ekstrapiramidnye violations). Imipramine can provoke obsession in patients with bipolar depression disorder, and should not be appointed to the obsessive episode. When using tricyclic antidepressants for the treatment of panic disorder may be a disturbing paradox mark for a period of not more than two weeks (to the appointment derivatives benzodiazepine). Before and during the period of treatment to be constant monitoring of the patient by health-care professionals and regular monitoring of the AD picture blood, ECG, functional state of the liver. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Storage conditions

List B. In the dark place at a temperature of 15-25 ° C

Shelf life

2

The registration

014539/01-2002

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