Metralindole

Chemical name

2,4,5,6-Тетрагидро-9-мето��си-4-метил-1Н-3,4,6а-триа��афлуорантен (as hydrochloride)

Gross

C15-H17-N3-O

Characteristics

White or white with kremovatam white crystalline powder. Rat in water and methanol, it is difficult soluble in ethanol, little soluble in chloroform, almost nerastvorim broadcast.

Of drugs

Drugs, the antidepressant. Ingibiruet reversible MAO type A and type of B. stops reverse takeover monoaminov increases norarenalin- and serotoninergicescuu transfer Zns.vozmozhno use in patients who protivopokazana antidepressants, the holinoliticaskoy activity in glaucome, hyper prostate cancer, etc.

Indications

Depression different genesis in schizophrenia, маниакально-депресси��ном psychosis, organic diseases brain ticlotimii, vascular diseases, etc.) dominated hypothesis and anergicakih disorders; valoapatical and adinamical depression with inhibition, shallow depression with neurozopodobna and nevarajenna ipohondricescoy symptoms; alcoholism, asteno-adinamicakie subdepressivee state (the percentage).

Contraindications

Ajitirovanne depression (possibly increasing alarming symptoms); Liver and / or kidney failure; Alcohol withdrawal syndrome.

Side-Effects

Nausea, dry mouth, of the gastric discomfort, fluctuations AD aetiology.

Specific guidance

In the absence of effective within 7 to 10 days to override the drug. It is the combination of tricyclic antidepressants and tranquilizers in the deep, protracted resistant endogenous depression, inwalutini melanholia with neiroleptikami, with the emergence of Shizofrenia.pri side effects should be reduced dose or interrupt the reception.

Patient interaction

Do pressorne effects of epinephrine, tiramina, fenamina, L-dofa, 5-oxitriptofana etc. Aminov.nesovmestim with MAO inhibitors (not should be appointed at the same time and during the two weeks after the sanctions have been lifted). Is rezerpina antagonist.

Precautions

Nor should designate product in the afternoon, it possibly worsening sleep.

Dosing and Administration

Inside, regardless of the meal. Initial dose 0,025-0,05 g 1-2 times a day (morning and afternoon). The dose increase at 0,025-0,05 g / day every 2-3 days until a therapeutic effect. Optimal dose-0.1-015 g / sut. The daily dose can be increased to 0.25 g. The course of treatment for 1-2 weeks to four months or longer.

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