Mianserin

Chemical name

1,2,3,4,10,14b-Гексагидро-2-м етилдибензо[c,f]пирази��о[1,2-a]азепин (as hydrochloride)

Gross

C18-H20-N2

Characteristics

The white crystalline powder and odourless, solubility in water 1:50 in 1:100 alcohol, in chloroform 1:20; PH 1% solution in water-4,0-5,5, svetochuvstvitelen.

Of drugs

Drugs, the antidepressant, sedative, sleeping. Does 5-HA_2 receptors and альфа_2-адренергическ��е receptors. Do adrenergic transfer to the brain, as stimulates breeding mediator in sinapticescuu slot as a result of the embargo presinapticakih альфа_2-адренорецепто��ов. Unlike most tricyclic antidepressants is not holinoliticaskoy Aguosti.bystro absorbed from the digestive tract, but low bioavailability (20%) due to a "first walk" through the Russians active tissues (mucous membranes intestines, liver). After receiving 15 mg inside C_max is 2-4 h of 6-19 ng / ml of plasma. Equilibrium concentration in the face of periodic reception of a six days. Almost entirely associated with plasma proteins (96%), display (partly in the form of metabolites) for the 70% of kidney and 8-28% intestinal. T_1/2 an average of 32 hours, to make mianserin once a day.

Indications

Depression (endogenous and reactive), inwalutinaya melanholia.

Contraindications

Maniakalny syndrome, liver diseases, acute cardiac period, pregnancy, breast-feeding (at the end of treatment), Children and Youth age (up to 18 years).

Side-Effects

Fall (in the early days of admission), arterial gipotenzia, gipomaniakale condition of the liver, oedema, ginekomastia, changes in cellular composition of the blood (obratimaya lakopenia and agranulozitos), convulsions, jaundice, arthritis, artralgia.

Patient interaction

Incompatible with MAO inhibitors (after a two-week interval), strengthens deprimirotee influence of alcohol, the effects of gipotenziveh weakens - anticonwulsantov.

Precautions

It should refrain from driving and other active and potentially dangerous activities requiring attention and quick reactions to refuse to accept alcohol. In gipomaniakalnah conditions and convulsions reactions treatment ceased. With improved sentiment, in order to maintain that effect mianserin take in the next few months. There is a need to carefully monitor patients with heart, kidney and / or liver failure, uzkougolna glaucoma and suspected suffering prostate gland. In the event of a fever, pharyngitis, stomatitis, and other infectious diseases requiring blood.

Dosing and Administration

Inside, with liquid squeezed water, preferably at night, it may be a few tricks. Initial dose, 30 mg, effective, 30-90 mg / day (preferably 60 mg), older-30 mg / day with a gradual increase in doses under the supervision of a physician.

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