Milnacipran

Chemical name

({+})цис-2-(Аминометил)-N,N -диэтил-1-фенилциклопр опанкарбоксамид

Gross

C15-H22-N2-O

Of drugs

Drugs, the antidepressant. Ingibiruet reverse takeover norarenalina and serotonin. Equalizes pathologically changed, depressive mood, normalizes the emotional sphere. Improves and accelerates the processes of thinking and more focus on Depresciah.posle reception inside quickly and almost completely absorbed; Bioavailability is 85% C_max achieved in 2 hours Metabolised mainly by conjugation with glukuronova acid. T_1/2-8 pm In small quantities crosses the placental barrier and in breast milk. Excreted mainly kidneys (90%) in an unmodified form. After repeated receptions completely withdrawn from the body in a couple of days after the repeal.

Indications

Depressive state.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, clean giperplazia prostate cancer, simultaneous inhibition of MAO B, selective inhibitors of reverse takeover neironalnogo serotonin, adrenaline, norarenalina, clonidine, digoxin, moklobemida, toloxton, pregnancy, breast-feeding, child and adolescence (15 years).

Side-Effects

Dizziness, sweating, tides, tremor, palpitations, dry mouth, nausea, neuralgia, dizuria, increasing transaminaz.

Patient interaction

Incompatible with MAO inhibitors and serotoninergicakimi control (type triptofana and fenfluramina). Ingibiruet gipotenzivny effect of clonidine and its derivatives. Changes level of lithium in blood. Epinephrine and provoke norapinefrin development gipertoniceski kriza and arrhythmias. Digoxin increases gemodinamicakie disorder.

Precautions

Patients with kidney failure to reduce doses depending on Cl creatinine. Between meals MAO inhibitors and milnatiprana a two-week interval. The therapy should not be used with alcohol. It must be borne in mind that at the beginning of treatment could increase their anxiety.

Dosing and Administration

Inside (preferably at meal times), 50 mg twice a day for several months.

Directory → Neurotropic funds → 24.2.1 → Milnacipran