Paroxetine

Chemical name

(3S-транс)-3-[(1,3-Бензодио ксол-5-илокси)метил]-4-(4 -фторфенил)пиперидин

Gross

C19-H20-F-N-O3

Characteristics

Colorless powder odourless.

Of drugs

Drugs, the antidepressant. Ingibiruet reverse takeover serotonin neurons increases serotoninergicescuu transfer to the central nervous system. Completely absorbed in the digestive tract. Time to C_max blood - 5.2 hours Connection with the plasma protein-95%. Intensive metabolised, metabolites have shown pharmacological activity. Approximately 64% excreted in the urine and 36% via blood (unchanged to 2% and 1%, respectively). T_1/2 - 2130 Concentration equilibrium is achieved in approximately 10 days, with daily admission to 30 mg. Decreases anxiety, depression. The effect is manifested in 10 days.

Indications

Depression different etiology, obsessions compoulsivee condition panic disorder.

Restrictions on the use of

Zakratougolnaya glaucoma, prostate adenoma cancer, pregnancy (a permissible only when strictly necessary), breast-feeding (it is necessary to abandon breastfeeding).

Contraindications

Гиперчувствительност ь and the two-week period following the lifting of MAO inhibitors.

Side-Effects

Drowsiness or insomnia, tremor, nervousness, anxiety agent, a violation of concentration, emotional lability, amnesia, dizziness, paresis ccomodation, expansion missed, the pain in the eyes, noise and pain in the ears, and gains AD condition, tachycardia, or aetiology, the cardiac conduction and peripheral blood circulation, cough, rhinitis, dipnoe, tahipnoe, nausea, reduced appetite, neuralgia, Enhancement of liver transaminaz, disease, artralgia, arthritis, dizuria, poliuria, urinary whose influence, amenorea, dismenorea, miscarriage, mastit breach findings, declining libido and potency, peripheral oedema, reduction or increase in body mass index, anemia, lakopenia, allergic reaction (itching, urticaria, vomiting). Rarely violations thinking, akinesia, ataxy, convulsions, hallucinations, giperkinesia, maniakale or paranoid reactions deliri, euphoria great epileptic seizures, aggressiveness, movement, stalemate, autism, eye, cataracts, conjunctivitis, glaucoma, exofthalm, stenocardia, heart attack, a breach of cerebral circulation, the disruptions to the heart, eozinofilia, leucocytosis, limfozitos, monocitos, gematuria, nefrourolitiaz violation of kidney function, dermatitis, uzlovataya erythema, Depigmentation.

Patient interaction

Inductive mikrosomalnogo oxidation (phenobarbital, phenytoin) reduce the concentration in the blood and active inhibitors (zimetidin) increase. Increases the protsyklidina plasma. Incompatible with MAO inhibitors. Joint appointment with indirect antikoagulyantami can cause increased bleeding in constant largest protrombinovogo time. Do the alcohol.

Overdosing

Symptoms : nausea, vomiting, drowsiness, sinusova tachycardia, increased inhibition and Dr.lechenie : symptomatic. To remove from the stomach nevsosavcheixia part of the preparation should be cause vomiting or a stomach wash.

Precautions

Before treatment to find out whether the disease episode mania or seizures. The lower dose in sharing with other antidepressants (nortriptilin, amitriptyline, imipramin, desipramin, fluoxetin) derivatives fenotiazina (tioridazin) and antiaritmicakimi drugs Class I (propafenon, flekainid, enkainid). Not recommended admission triptofana. Be wary appoint persons engaged in potentially hazardous activities that require greater attention, as well as the rapid mental and motor reactions.

Dosing and Administration

Inside, on the morning of 20 mg. If the effect can increase the doses of 10 mg / day at intervals of not less than 1 hour (maximum dose, 50 mg / day). The elderly, debilitated patients, as well as in violation of the kidney and liver initial dose of 10 mg / day, maximum 40 mg / sut.

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