Pipofezine

Chemical name

5-Метил-3-(4-метил-1-пипе��азинил)-5Н-пиридазино[ 3,4b][1,4]бензоксазин (as hydrochloride)

Gross

C16-H19-N5-O

Characteristics

Crystalline powder zelenovato-jeltogo color. Easily soluble in water, virtually nerastvorim in alcohol.

Of drugs

Drugs, the antidepressant, sedative. Indiscriminately ingibiruet return neironalny hostage presinapticescoy bursting of the synaptic junctions serotonin and norarenalina, leading to a rise in their concentrations and kupirovaniu symptoms of depression. Unlike other antidepressants of the group virtually no holinoliticaskoy activity and does not affect the activity Mao.bystro and completely absorbed from the digestive tract. Bioavailability is about 80%. C_max blood achieved in 2 hours Connection with the plasma protein-high (around 90%). Treated biotransformation in the liver with the formation of active metabolites. T_1/2 - 1630 Excreted in the kidney.

Indications

Endogenous and exogenous depression and depressive state of chronic somatic diseases.

Restrictions on the use of

Pregnancy, breast-feeding. There is no information on the safety of the children. Contraindicated sharing with antidepressants, MAO inhibitors.

Contraindications

Hypersensitivity, renal failure, heart failure, myocardial infarction, ischemic heart disease, post-acute violations of cerebral circulation, severe infectious diseases, and diabetes mellitus.

Side-Effects

Headache, dizziness, nausea, vomiting, allergic reactions.

Patient interaction

Potenziruet effects of alcohol and other means, oppressive CNS, antigistaminnah and anticoagulants. Reduces the protivosudorojna therapy.

Dosing and Administration

Inside. Initial dose for adults 25-50 mg in two stages (morning and afternoon). With good endurance gradually increased to 150 mg / day and, in some cases, up to 400 mg. In achieving the desired effect affect the supporting-dose 75 mg / sut. The course is not less than one and one half months.

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