Pirazidol

Roman name

Pyrazidolum

The composition and the form of

1 tablet contains pirlindola hydrochloride 0,025 g or 0.05 g; in the polymer banks to 50 pc. , in a cardboard bundle one bank.

Of drugs

Antidepressive, properties. Selectively ingibiruet monoaminoxydazu (MAO) type A, dezaminirovanie blocking serotonin and norarenalina, to a lesser 15772 extent, tiramina. Partly ingibiruet return monoaminov hostage. Does adrenergicakie structure by potenzirovania effects predecessor norepinephrine - dioksifenilalanina (L-dofa) serotoninergicakie structure, through potenzirovania effects predecessor серотонина–5-окситри��тофана. Activates the cholinergic transmission of nerve excitation in the central nervous system. Improves cognitive (cognitive) function. There has antiholinergicakim action.

Farmakodinamika

Antidepressant effect, in conjunction with timolepticski action is a balanced effect on the central nervous system (aguirutee effect in patients with apaticakimi, anergicakimi depression combined with sedative effect in patients with ajitirovannami states).

Indications

Senillnaya, inwalutinaya depression and other disorders of different etiology (including running with psychomotor slowing and asthenia disorders тревожно-депрессивны��и trevojno-bredovmi or components), alcohol withdrawal syndrome, Alzheimer's disease (composed of combination therapy).

Contraindications

Hypersensitivity, acute hepatitis, diseases of the blood, simultaneous MAO inhibitors.

Side-Effects

Brown mouth, nausea, sweating, tremor hands, tachycardia, dizziness, allergic reactions.

Patient interaction

Ters depressive effects rezerpina enhances epinephrine (in connection with антимоноаминоксидазн ой activity). Compatible with antipsychotic means anxiolitikami. Not compatible with antidepressants, MAO inhibitors, furazolidonom, procarbazine, selegilinom.

Precautions

After MAO inhibitors therapy beginning not earlier than 14 days. Lack of holinoblokirutego allows drug in patients with glaucoma and adenoma prostate gland.

Dosing and Administration

On the inside 0,05-0,075 g / day in 2 admission and gradually increasing the dose 0,025-0,05 g to auxiliary g / sut. The maximum daily dose of 0.4 grams divided by the reception 2-3. Following the therapeutic effect of the treatment continues individually tailored dose over a period of two to four weeks, after which the dose is gradually reduced.

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